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Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium(Open Access)

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机构: [a]Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands [b]Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States [c]Department of Clinical Neuroscience, Osher Centre, Karolinska Institutet, Stockholm, Sweden [d]Norwegian Centre for Mental Disorders Research (NORMENT), K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway [e]Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm County Council, Stockholm, Sweden [f]Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway [g]Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Lab, NCBES Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences, National University of Ireland Galway, Galway Ireland, H91 TK33, Ireland [h]BCN Neuroimaging Center, Department of Neuroscience, University Medical Center Groningen, University of Groningen, Netherlands [i]Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland [j]Neurology and Neurosurgery Department, Montreal Neurological Hospital and Institute, McGill University, Montreal, Canada [k]Orygen, National Centre of Excellence in Youth Mental Health, Parkville, Australia [l]Department of Psychology, University of Oregon, Eugene, OR, United States [m]National Ageing Research Institute, Melbourne, Australia [n]Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia [o]Norwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Oslo, Norway [p]Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands [q]Department of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands [r]Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands [s]Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands [t]Mathematics and Statistics, Murdoch University, Perth, Australia [u]Laboratory of Neuroimaging, Department of Neurology, University of Campinas, Brazil [v]Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom [w]Brain Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom [x]Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands [y]Department of Clinical Radiology, School of Medicine, University of Münster, Germany [z]Discipline of Psychiatry, University of Adelaide, Australia [aa]Department of Psychology, University of Würzburg, Germany, Würzburg, Germany [ab]Department of Psychiatry, Harvard Medical School, Boston, MA, United States [ac]Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, United States [ad]Department of Psychiatry, VU University Medical Center, Amsterdam, Netherlands [ae]Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, Netherlands [af]Amsterdam Neuroscience, Amsterdam, Netherlands [ag]Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India [ah]Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands [ai]Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland [aj]Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland [ak]Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland [al]Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, Mannheim, 68159, Germany [am]Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Australia, Australia [an]Dementia Collaborative Research Centre ØC Assessment and Better Care, University of New South Wales, Sydney, Australia [ao]Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany [ap]Department of Psychiatry and Mental Health, University of Cape Town, South Africa [aq]Karakter Child and Adolescent Psychiatry, Nijmegen, Netherlands [ar]Department of Cognitive Neuroscience, Radboud University, Nijmegen, Netherlands [as]Department of Psychiatry, University of Münster, Germany [at]Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany [au]Mind Research Network, Albuquerque, NM, United States [av]Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM 87131, United States [aw]Medical Image Core Facility, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain [ax]CIBERBBN, Spain [ay]FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain [az]CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental, Spain [ba]Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland [bb]Signal Processing Laboratory 5 (LTS5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland [bc]Departments of Psychiatry and Neurosciences, University of New Mexico, United States [bd]Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States [be]Department of Child and Adolescent Psychiatry, Hassenfeld Children's Hospital at NYU Langone, New York, United States [bf]Division of Clinical Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, United States [bg]Department of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil [bh]Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo, São Paulo, Brazil [King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Child and Adolescent Psychiatry, London, United Kingdom]biKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Child and Adolescent Psychiatry, London, United Kingdom [bj]School of Psychology, Southwest University, Chongqing, China [bk]Key Laboratory of Cognition and Personality, Ministry of Education, Chongqing, China [bl]State Key Lab. of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Faculty of Psychology, Beijing Normal University, Beijing, China [bm]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China [bn]Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, London, WC2R 2LS, United Kingdom [bo]School of Psychology and Clinical Language Sciences, University of Reading, Reading, RG6 6AL, United Kingdom [bp]Department of Psychology, University of New Mexico, Albuquerque, NM 87131, United States [bq]Departments of Paediatrics and Psychiatry, University of Melbourne, VIC, Australia [br]Division of Neuroscience, Ninewells Hospital and Medical School, University of Dundee, United Kingdom [bs]Department of Biomedical Sciences, Florida State University, Tallahassee, FL 32306, United States [bt]Department of Psychiatry, Division of Child and Adolescent Psychiatry, and Weill Institute for Neurosciences, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA, United States [bu]Department of Child and Adolescent Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany [bv]Norwegian Centre for Mental Disorder Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway [bw]Department of Developmental Psychology, University of Amsterdam, Amsterdam, Netherlands [bx]SANE POWIC, University Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom [by]Departments of Neurosciences and Radiology, University of California, San Diego, San Diego, CA, United States [bz]UCSD Center for Translational Imaging and Precision Medicine, San Diego, CA, United States [ca]NICHE-lab, Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, Netherlands [cb]Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, United Kingdom [cc]Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, United States [cd]Kimel Family Translational Imaging-Genetics Research Laboratory, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, Canada [ce]Neurology Department, St. James's Hospital, Dublin, Ireland [cf]Department of Psychiatry, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States [cg]Stanley Center for Psychiatric Research at the Broad Institute, Cambridge, MA, United States [ch]Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany [ci]Norwegian Centre for Mental Disorder Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway [cj]Department of Neurology, Oslo University Hospital, Oslo, Norway [ck]University of Cincinnati, College of Medicine, Cincinnati, OH, United States [cl]Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States [cm]Department of Behavioral Neuroscience, Oregon Health and Science University, United States [cn]Department of Psychiatry, Oregon Health and Science University, United States [co]Advanced Imaging Research Center, Oregon Health and Science University, United States [cp]K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway [cq]Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, United States [cr]Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands [cs]Institute of Psychiatric Phenomics and Genomics (IPPG), Ludwig-Maximilians-University, Munich, Germany [ct]Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa [cu]Ernest J. Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, United States [cv]Department of Psychiatry and Psychotherapy, University Hospital, Otto-von-Guericke-University, Magdeburg, Germany [cw]Neuroscience Research Australia, Sydney, NSW, Australia [cx]School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia [cy]Department of Psychiatry, University of Vermont, Burlington, VT, United States [cz]Laboratory of Neuroimaging, Department of Neurology, University of Campinas, Campinas, Brazil [da]Department of Psychology, Stanford University, United States [db]Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands [dc]Arkin Mental Health and Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, Netherlands [dd]Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Germany [de]German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany [df]Interdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, Netherlands [dg]Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany [dh]Department of Psychiatry, Haukeland University Hospital, Bergen, Norway [di]Queensland Brain Institute, University of Queensland, Brisbane, Australia [dj]Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom [dk]Department of Psychiatry, University Medical Center Groningen, University of Groningen, Netherlands [dl]Department of Cognitive Psychology, VU University Amsterdam, Amsterdam, Netherlands [dm]Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, Netherlands [dn]School of Psychological Sciences, University of Melbourne, Melbourne, Australia [do]Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA 90292, United States [dp]Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA, United States [dq]Department of Psychology, Stanford University, Stanford, CA, United States [dr]University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, Netherlands [ds]Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands [dt]Department of Psychiatry, Amsterdam, Netherlands [du]Department of Clinical Medicine, University of Bergen, Bergen, Norway [dv]Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway [dw]De Bascule, Academic Center for Child and Adolescent Psychiatry, Amsterdam, Netherlands [dx]AMC, Department of Child and Adolescent Psychiatry, Amsterdam, Netherlands [dy]Department of Psychiatry, Oregon Health and Science University, Portland, OR, United States [dz]University Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom [ea]Departments of Cognitive Science, Psychiatry, Radiology, University of California, San Diego, CA, United States [eb]Center for Human Development, University of California, San Diego, CA, United States [ec]Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway [ed]Mental Health Research Center, Moscow, Russian Federation [ee]Department of Psychiatry, University of Dublin, Trinity College Dublin, Dublin, Ireland [ef]Child Study Center at NYU Langone Medical Center, New York, United States [eg]School of Psychology, Trinity College, Dublin, Ireland [eh]Trinity College Institute of Neuroscience, Dublin, Ireland [ei]Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Baltimore, MD, United States [ej]Beth Israel Deaconess Medical Center, Boston, MA, United States [ek]Olin Neuropsychiatry Research Center, Hartford, CT, United States [el]Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, University Hospital Aachen, Aachen, Germany [em]Department of Psychiatry, Washington University School of Medicine, St Louis, MO, United States [en]Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea [eo]Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea [ep]Institute of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden [eq]Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic, Barcelona, Spain [er]August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain [es]Department of Medicine, University of Barcelona, Barcelona, Spain [et]School of Psychiatry, University of New South Wales, Sydney, NSW, Australia [eu]University of New Mexico, Albuquerque, United States [ev]Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany [ew]Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation [ex]Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, Netherlands [ey]Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education (Beijing Normal University), Faculty of Psychology, Beijing Normal University, Beijing, China [ez]Department of Psychiatry, University of Minnesota, Minneapolis, MN, United States [fa]SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, South Africa [fb]Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, United States [fc]Institute of Psychology Health and Society, University of Liverpool, Liverpool, United Kingdom [fd]Behavioural Science Institute, Radboud University, Nijmegen, Netherlands [fe]Departments of Psychiatry and Pediatrics, University of Calgary, Calgary, AB, Canada [ff]Child and Adolescent Imaging Research Program, Alberta Children's Hospital, Calgary, AB, Canada [fg]Mathison Centre for Mental Health Research and Education, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada [fh]Strategic Clinical Network for Addictions and Mental Health, Alberta Health Services, Calgary, AB, Canada [fi]Alberta Children's Hospital Research Institute, Calgary, AB, Canada [fj]Institut des Maladies Neurodégénératives, UMR 5293. Groupe D'Imagerie Neurofonctionnelle, CEA - CNRS - Université de Bordeaux, Bordeaux, France [fk]Developmental Imaging, Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia [fl]Department of Research and Education, Oslo University Hospital, Oslo, Norway [fm]Institute of Clinical Medicine, University of Oslo, Oslo, Norway [fn]Department of Psychiatry and Psychology, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain [fo]Department of Psychiatry, Trinity College Dublin, Dublin, Ireland [fp]Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia [fq]Prince of Wales Hospital, Sydney, NSW, Australia [fr]Institut des Maladies Neurodégénératives, UMR 5293. Groupe D'Imagerie Neurofonctionnelle, CEA - CNRS - Université de Bordeaux, France [fs]Department of Neuroscience, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada [ft]Centre for Advanced Imaging, University of Queensland, Brisbane, Australia [fu]Neuropsychopharmacology Unit, Division of Brian Sciences, Imperial College London, London, United Kingdom [fv]Sunnaas Rehabilitation Hospital HT, Nesodden, Norway [fw]Center for MR-Research, University Children's Hospital, Zurich, Switzerland [fx]Emma Children's Hospital Amsterdam Medical Center, Amsterdam, Netherlands [fy]VU Medical Center, Amsterdam, Netherlands [fz]Clinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, Netherlands [ga]Laureate Institute for Brain Research, Tulsa, OK, United States [gb]Department of Psychiatry, University of California San Diego, San Diego, CA, United States [gc]Child and Adolescent Mental Health Center, Capital Region, Denmark [gd]Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Centro de Investigación Biomédica en Red de Salut Mental (CIBERSAM), Barcelona, Catalonia, Spain [ge]Centre for Psychiatric Research and Education, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden [gf]Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, United Kingdom [gg]Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain [gh]Department of Psychiatry, Hospital Universitari Vall D'Hebron, CIBERSAM, Barcelona, Spain [gi]Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany [gj]Department of Psychiatry and Behavioral Sciences, Stanford University, United States [gk]Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia [gl]Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia [gm]Translational Brain Research, Department of Child and Adolescent Psychiatry, University Hospital Aachen, Aachen, Germany [gn]Department of Child and Adolescent Psychiatry, University Hospital Aachen, Aachen, Germany [go]Neurobehavioral Clinical Research Section, National Human Genome Research Institute, Bethesda, United States [gp]National Institute of Mental Health, Bethesda, MD, United States [gq]Department of Paediatrics, University of Melbourne, Melbourne, Australia [gr]School of Psychology, Deakin University, Melbourne, Australia [gs]Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, San Diego, CA, United States [gt]Veterans Affairs San Diego Health Care System, San Diego, CA, United States [gu]Max Planck Institute for Human Cognitive and Brain Sciences, Department of Neurology, Leipzig, Germany [gv]Leiden University, Institute of Psychology, Cognitive Psychology Unit, Leiden Institute for Brain and Cognition, Leiden, Netherlands [gw]School of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia [gx]Minneapolis VA Health Care System and University of Minnesota, Minneapolis, MN, United States [gy]SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, South Africa [gz]Clinical Neuroscience and Development Laboratory, Olin Neuropsychiatry Research Center, Hartford, CT, United States [ha]Child and Adolescent Research, Hartford Hospital, Institute of Living, Hartford, CT, United States [hb]Department of Psychiatry, Yale University School of Medicine, Hartford, CT, United States [hc]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China [hd]Department of Pediatrics, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States [he]Department of Psychiatry and Behavioral Sciences, University of New Mexico, Albuquerque, NM, United States [hf]Department of Psychiatry, University of New Mexico, Albuquerque, NM, United States [hg]Department of Psychology and Neuroscience Institute, Georgia State University, Atlanta, GA 30302, United States [hh]Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, United States [hi]K.G. Jebsen Centre for Psychosis Research, Norwegian Centre for Mental Disorder Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway [hj]School of Psychology, University of Queensland, Brisbane, Australia [hk]Academic Child Psychiatry Unit, Royal Children's Hospital, University of Melbourne, Melbourne, VIC, Australia [hl]Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Mitte, Berlin, Germany [hm]Fundació IMIM, Barcelona, Spain [hn]INNDACYT, Barcelona, Spain [ho]Department of Psychiatry, University of Toronto, Toronto, Canada [hp]Institute for Community Medicine, University Medicine Greifswald, Germany [hq]DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Germany [hr]German Centre for Diabetes Research (DZD), Site Greifswald, Germany [hs]Department of Psychology, Georgia State University, Atlanta, GA, United States [ht]Brain Research Imaging Centre, Centre for Clinical Brain Sciences and Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom [hu]Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, United Kingdom [hv]Centre for Clinical Brain Sciences, Centre for Cognitive Ageing and Cognitive Epidemiology, UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom [hw]NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Oslo, Norway [hx]Department of Psychology, University of Oslo, Oslo, Norway [hy]Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre, Rotterdam, Netherlands [hz]Department of Radiology, Erasmus University Medical Centre, Rotterdam, Netherlands [ia]Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Melbourne, Australia [ib]Seoul National University Hospital, Seoul, South Korea [ic]Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, South Korea [id]Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia [ie]Olin Neuropsychiatric Research Center, Hartford, CT, United States [if]Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands [ig]Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands [ih]Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands [ii]Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden [ij]Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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关键词: Brain asymmetry Cortical thickness Lateralization Meta-analysis Surface area

摘要:
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders. © 2018 National Academy of Sciences. All rights reserved.

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第一作者机构: [a]Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands
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