机构：[1]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan Province, P.R. China内科科室外科科室神经内科泌尿外科昆明医科大学附属第一医院[2]Department of Neurology, Seventh People’s Hospital of Chengdu, 690041 Chengdu, Sichuan Province, P.R. China[3]Department of medical imaging, First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan Province, P.R. China医技科室医学影像中心昆明医科大学附属第一医院[4]Department of Neurology, Qujing City First People’s Hospital, 655099 Qujing, Yunnan Province, P.R. China云南省第一人民医院[5]Department of neurosurgery, First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan Province, P.R. China外科科室神经外科神经外一科（神经外科）昆明医科大学附属第一医院[6]Department of Neurology, First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan Province, P.R. China内科科室外科科室神经内科泌尿外科昆明医科大学附属第一医院[7]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan Province, P.R. China内科科室外科科室神经内科泌尿外科昆明医科大学附属第一医院
We aimed to perform a combined analysis of cortical thickness and functional connectivity to explore their association with cognitive impairment in Parkinson's disease (PD). A total of 53 PD and 15 healthy control subjects were enrolled. PD patients were divided into PD with normal cognition (PD-NC, n = 25), PD with mild cognitive impairment (PD-MCI, n = 11), and PD with dementia (PDD, n = 17). In some analyses, the PD-MCI and PDD groups were aggregated to represent "PD patients with cognitive impairment". Cognitive status was assessed with the Mini-Mental State Examination (MMSE). Anatomical magnetic resonance imaging and resting-state functional connectivity analysis were performed in all subjects. First, surface-based morphometry measurements of cortical thickness and voxels with cortical thickness reduction were detected. Then, regions showing reduced thickness were analyzed for changes in resting-state functional connectivity in PD involving cognitive impairment. Our results showed that, compared with PD-NC, patients with cognitive impairment showed decreased cortical thickness in the left superior temporal, left lingual, right insula, and right fusiform regions. PD-MCI patients showed these alterations in the right lingual region. Widespread cortical thinning was detected in PDD subjects, including the left superior temporal, left fusiform, right insula, and right fusiform areas. We found that cortical thinning in the left superior temporal, left fusiform, and right temporal pole regions positively correlated with MMSE score. In the resting-state functional connectivity analysis, we found a decrease in functional connectivity between the cortical atrophic brain areas mentioned above and cognition-related brain networks, as well as an increase in functional connectivity between those region and the cerebellum. Alterations in cortical thickness may result in a dysfunction of resting-state functional connectivity, contributing to cognitive decline in patients with PD. However, it is more probable that the relation between structure and FC would be bidirectional,and needs more research to explore in PD cognitve decline.
基金：
Yunnan Province Clinical Research Center for Neurological Diseases [202002AA100204]; Clinical Research Center for Geriatric Diseases of Yunnan Province [202102AA310069]; National Natural Science Foundation of China [81960242]; Chengdu Medical College - Chengdu Seventh People's Hospital Joint Scientific Research Fund [2020LHJYZD-02]; Yunnan Applied Basic Research Project [2019FE001-048, 202001AT070001]; Special clinical research project for young and middle-aged Doctors in Lingnan Neurology Department; Major Science and Technology Special Project of Yunnan Province [202102AA100061, 202103AA100069]
第一作者机构：[1]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan Province, P.R. China
通讯作者：
通讯机构：[1]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan Province, P.R. China[7]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan Province, P.R. China
推荐引用方式(GB/T 7714)：
Yongyun Zhu,Baiyuan Yang,Chuanbin Zhou,et al.Cortical atrophy is associated with cognitive impairment in Parkinson's disease: a combined analysis of cortical thickness and functional connectivity[J].BRAIN IMAGING AND BEHAVIOR.2022,16(6):2586-2600.doi:10.1007/s11682-022-00714-w.
APA：
Yongyun Zhu,Baiyuan Yang,Chuanbin Zhou,Chao Gao,Yanfei Hu...&Xinglong Yang.(2022).Cortical atrophy is associated with cognitive impairment in Parkinson's disease: a combined analysis of cortical thickness and functional connectivity.BRAIN IMAGING AND BEHAVIOR,16,(6)
MLA：
Yongyun Zhu,et al."Cortical atrophy is associated with cognitive impairment in Parkinson's disease: a combined analysis of cortical thickness and functional connectivity".BRAIN IMAGING AND BEHAVIOR 16..6(2022):2586-2600
