机构：[1]Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming, China内科科室内分泌科昆明医科大学附属第一医院[2]Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, China内科科室精神科昆明医科大学附属第一医院[3]Department of MRI, The First Affiliated Hospital of Kunming Medical University, Kunming, China昆明医科大学附属第一医院
Aims: Although hypertension (HTN) is the high comorbidity of Type 2 diabetes mellitus (T2DM) and known to be a vascular risk factor for brain damage, the effects of HTN on brain function in T2DM patients are not well understood. Present study was performed to investigate whether HTN might accelerate the Cerebral cortical thickness (CT) alterations in patients with T2DM. Methods: We enrolled 35 participants with only T2DM, 25 T2DM patients with HTN (HT2DM) and 28 healthy controls (HCs). The cognitive function was assessed and brain image data was collected then the CT was calculated for each participant. Partial correlations between the CT of each brain region and standard laboratory testing data and neuropsychological scale scores were also analyzed. Multivariable regression analysis was performed to evaluated the vascular risk factors and brain regions with different CT in HT2DM patients. Results: Cognitive impairment is associated with thinning of the cerebral cortical thickness reduction in T2DM patients. CT thinning in the left inferior parietal lobe, left posterior cingulate and right precuneus were observed in HT2DM group relative to only T2DM group. Furthermore, the CT decreasing in the right precuneus was negatively correlated with duration of HTN. Conclusion: The current study revealed that coexistent HTN may accelerate the CT reduction in T2DM patients. (C) 2019 Elsevier B.V. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81560233, 81660237]; Founding of Yunnan Provincial Health Science and Technology Plan [2016NS026, 2018NS0109]; Yunnan Applied Basic Research Projects-Union Foundation [2017FE467(-167), 2017FE468(-176), 2018FE001(-209)]; Innovative Research Team of Yunnan Province [2017HC004]; Innovative Research Team of Kunming Medical University [CXTD201705]; Middle and Young Aged Academic and Technology Leaders Reserve Personnel Foundation of Yunnan Province [2017HB062]
第一作者机构：[1]Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming 650032,China.
推荐引用方式(GB/T 7714)：
Shi Li,Cheng Yuqi,Xu Yushan,et al.Effects of hypertension on cerebral cortical thickness alterations in patients with type 2 diabetes[J].DIABETES RESEARCH AND CLINICAL PRACTICE.2019,157:doi:10.1016/j.diabres.2019.107872.
APA：
Shi, Li,Cheng, Yuqi,Xu, Yushan,Shen, Zonglin,Lu, Yi...&Xu, Xiufeng.(2019).Effects of hypertension on cerebral cortical thickness alterations in patients with type 2 diabetes.DIABETES RESEARCH AND CLINICAL PRACTICE,157,
MLA：
Shi, Li,et al."Effects of hypertension on cerebral cortical thickness alterations in patients with type 2 diabetes".DIABETES RESEARCH AND CLINICAL PRACTICE 157.(2019)
