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Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families

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收录情况： ◇ SCIE

作者：
Yang, Ying[1,2] * ; Zhou, Taicheng[1,3,4] ; Peng, Minsheng[4,5] ; Liu, Yongying[2] ; Li, Yiping[2] ; Wang, Huawei[6] ; Irwin, David M.[4,7] ; Zhang, Yaping[1,3,4,5] ;
机构： [1]Yunnan Univ, Lab Conservat & Utilizat Bioresources, Kunming, Yunnan Province, Peoples R China [2]Second Peoples Hosp Yunnan Prov, Dept Endocrinol, Kunming, Yunnan Province, Peoples R China [3]Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Yunnan Province, Peoples R China [4]Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan Province, Peoples R China [5]KIZ CUHK Joint Lab Bioresources & Mol Res Common, Kunming, Yunnan Province, Peoples R China [6]Kunming Med Univ, Affiliated Hosp 1, Yunnan Inst Digest Dis, Kunming, Yunnan Province, Peoples R China [7]Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
出处：
DOI： 10.3109/19401736.2014.982552
ISSN：

关键词： diabetes haplogroup mitochondrial DNA multiple origins private mutations

摘要：
Previous work suggests that mitochondrial DNA (mtDNA) derived from the maternal genome has a close affinity with type 2 diabetes. This would support a familial pattern for type 2 diabetes. Thereby, we analyzed complete mtDNA genomes from two families, A and B, from Southwest China that demonstrated maternally inherited type 2 diabetes. Our data support that mtDNA lineages from families A and B belong to haplogroups A4 and D4h1, respectively. This suggests that maternally inherited type 2 diabetes with similar penetrances can arise in Chinese individuals with strikingly different maternal genetic backgrounds. Two private coding region mutations (G13759A in MT-ND5 and G15930A in tRNA-Thr) were identified in family B. Further evolutionary and phylogenetic analyses suggest that both these mutations have multiple origins and are unlikely to be disease causing.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81260135]; training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province [2011CI045]; fund of medical leader in Yunnan Province [D-201217]; Youth Innovation Promotion Association, Chinese Academy of Sciences
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外文
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中科院(CAS)分区：
出版当年[2017]版：
大类 | 3 区 生物
小类 | 4 区 遗传学
最新[2023]版：
无
JCR分区：
出版当年[2016]版：
Q4 GENETICS & HEREDITY
最新[2023]版：
Q4 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Yunnan Univ, Lab Conservat & Utilizat Bioresources, Kunming, Yunnan Province, Peoples R China [2]Second Peoples Hosp Yunnan Prov, Dept Endocrinol, Kunming, Yunnan Province, Peoples R China
通讯作者：
通讯机构： [4]Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan Province, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Ying,Zhou Taicheng,Peng Minsheng,et al.Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families[J].MITOCHONDRIAL DNA PART A.2016,27(3):2040-2044.doi:10.3109/19401736.2014.982552.
APA：
Yang, Ying,Zhou, Taicheng,Peng, Minsheng,Liu, Yongying,Li, Yiping...&Zhang, Yaping.(2016).Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families.MITOCHONDRIAL DNA PART A,27,(3)
MLA：
Yang, Ying,et al."Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families".MITOCHONDRIAL DNA PART A 27..3(2016):2040-2044

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