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Gout Is Not Just Arthritis: Abnormal Cortical Thickness and Structural Covariance Networks in Gout.

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收录情况： ◇ SCIE

作者：
Yifan Yang[1] * ; Yuqi Cheng[2] ; Xiangyu Wang[1] ; Bibhuti Upreti[1] ; Ruomei Cui[1] ; Shuang Liu[1] ; Baoci Shan[3] ; Hongjun Yu[4] ; Chunrong Luo[4] ; Jian Xu[1] ;
机构： [1]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, China, [2]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China, [3]Nuclear Analysis Technology Key Laboratory, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China, [4]Magnetic Resonance Imaging Center, The First Hospital of Kunming, Kunming, China
出处：
DOI： 10.3389/fneur.2021.662497
ISSN：

关键词： gout brain cortical thickness structural covariance networks graph theory

摘要：
Background: Hyperuricemia is the cause of gout. The antioxidant and neuroprotective effects of uric acid seem to benefit some patients with central nervous system injury. However, changes in the brain structure have not been discovered in patients with gout. Object: Clarify the changes in cortical thickness in patients with gout and the alteration of the structural covariance networks (SCNs) based on cortical thickness. Methods: We collected structural MRIs of 23 male gout patients and 23 age-matched healthy controls. After calculating and comparing the difference in cortical thickness between the two groups, we constructed and analyzed the cortical thickness covariance networks of the two groups, and we investigated for any changes in SCNs of gout patients. Results: Gout patients have thicker cortices in the left postcentral, left supramarginal, right medial temporal, and right medial orbitofrontal regions; and thinner cortices were found in the left insula, left superior frontal, right pericalcarine, and right precentral regions. In SCN analysis, between-group differences in global network measures showed that gout patients have a higher global efficiency. In regional network measures, more nodes in gout patients have increased centrality. In network hub analysis, we found that the transfer of the core hub area, rather than the change in number, may be the characteristic of the gout's cortical thickness covariance network. Conclusion: This is the first study on changes in brain cortical thickness and SCN based on graph theory in patients with gout. The present study found that, compared with healthy controls, gout patients show regional cortical thinning or thickening, and variation in the properties of the cortical thickness covariance network also changed. These alterations may be the combined effect of disease damage and physiological compensation. More research is needed to fully understand the complex underlying mechanisms of gout brain variation.Copyright © 2021 Yang, Cheng, Wang, Upreti, Cui, Liu, Shan, Yu, Luo and Xu.

基金：
This work was supported by grants from the National Natural Science Foundation of China (81760296, 82060259, and 81460256), Yunnan Province High-level health technical talents (leading talents) (L-2019004 and L2019011), Yunnan Province Special Project for Famous Medical Talents of the “Ten Thousand Talents Program” (YNWRMY- 2018-040 and YNWR-MY-2018-041), the Funding of Yunnan Provincial Health Science and Technology Plan (2017NS051 and 2018NS0133), the Funding of Ministry of Science and Technology of Yunnan Province (2018ZF016), Yunnan Province Clinical Research Center for Skin Immune Diseases (2019ZF012), and Yunnan Province Clinical Center for Skin Immune Diseases (ZX2019-03-02).

基金编号： 81760296, 82060259, and 81460256

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 神经科学 3 区 临床神经病学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经科学
JCR分区：
出版当年[2021]版：
Q2 CLINICAL NEUROLOGY Q2 NEUROSCIENCES
最新[2023]版：
Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Yifan Yang,Yuqi Cheng,Xiangyu Wang,et al.Gout Is Not Just Arthritis: Abnormal Cortical Thickness and Structural Covariance Networks in Gout.[J].FRONTIERS IN NEUROLOGY.2021,12:doi:10.3389/fneur.2021.662497.
APA：
Yifan Yang,Yuqi Cheng,Xiangyu Wang,Bibhuti Upreti,Ruomei Cui...&Jian Xu.(2021).Gout Is Not Just Arthritis: Abnormal Cortical Thickness and Structural Covariance Networks in Gout..FRONTIERS IN NEUROLOGY,12,
MLA：
Yifan Yang,et al."Gout Is Not Just Arthritis: Abnormal Cortical Thickness and Structural Covariance Networks in Gout.".FRONTIERS IN NEUROLOGY 12.(2021)

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