机构：[1]Department of Respiratory Medicine, Yunnan, China内科科室呼吸内科昆明医科大学附属第一医院呼吸与危重症一科呼吸内科内科科室[2]Department of Pharmacy, First Affiliated,Hospital of Kunming Medical University,Yunnan, China医技科室药剂科昆明医科大学附属第一医院[3]The Postgraduate School of KunmingMedical University, Kunming, Yunnan, China[4]Department of Respiratory Medicine, FirstAffiliated Hospital of Kunming Medical University, Yunnan, China
Background: The concentration of interleukin-27 (IL-27) in pleural effusions was found to be increased in tuberculous pleurisy and several studies have investigated the diagnostic value of IL-27 for tuberculous pleural effusions (TPEs), but the results varied a lot. We conducted the present study to comprehensively evaluate the diagnostic value of IL-27 for TPE. Methods: Primary diagnostic test studies of IL-27 for TPE was searched and identified from databases. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ration, diagnostic odds ratio, and receiver operating characteristic curves (SROCs) were computed or pooled to summarize the overall test performance. Results: Nine studies with a total number of 1226 patients were identified in our research. The main pooled estimates were as follows: sensitivity 0.92 [95% confidence interval (CI), 0.90-0.95], specificity 0.90 (95% CI, 088-0.92), and area under the SROC 0.97. No evidence of publication bias was detected. Conclusion: Our research suggested the good diagnostic value of IL-27 for TPE and it could be used as a diagnostic biomarker.
基金：
Scientific Research Fund Project of Yunnan Provincial Education Department [2015Y182, 2016ZDX053]
第一作者机构：[1]Department of Respiratory Medicine, Yunnan, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Respiratory Medicine, First Affiliated Hospital of Kunming Medical University, NO. 295 Xi Chang Road, Kunming, Yunnan 650032, P.R. China
推荐引用方式(GB/T 7714)：
Li Min,Zhu Wenye,Khan Rana Sami Ullah,et al.Accuracy of interleukin-27 assay for the diagnosis of tuberculous pleurisy A PRISMA-compliant meta-analysis[J].MEDICINE.2017,96(50):doi:10.1097/MD.0000000000009205.
APA：
Li, Min,Zhu, Wenye,Khan, Rana Sami Ullah,Saeed, Ummair,Wang, Rongchun...&Luo, Zhuang.(2017).Accuracy of interleukin-27 assay for the diagnosis of tuberculous pleurisy A PRISMA-compliant meta-analysis.MEDICINE,96,(50)
MLA：
Li, Min,et al."Accuracy of interleukin-27 assay for the diagnosis of tuberculous pleurisy A PRISMA-compliant meta-analysis".MEDICINE 96..50(2017)
