机构：[1]The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China昆明医科大学附属第一医院老年消化病区干疗科内科科室[2]Human Genetics Center of Yunnan University, Kunming, Yunnan, China[3]Institute of Medicinal Biology Chinese Academy of Medical Science, Kunming, Yunnan, China
miRNAs have been shown to play pivotal roles in the establishment and progression of colon cancer, but their underlying mechanisms are not fully understood. N-acetyltransferase NAA10 participates in many cellular processes, including tumorigenesis. Here we showed that miR-342-5p and miR-608 suppressed the tumorigenesis of colon cancer cells in vitro and in vivo by targeting NAA10 mRNA for degradation. Overexpression of miR-342-5p or miR-608 decreased NAA10 mRNA and protein levels and thereby suppressed cell proliferation, migration, and cell-cycle progression, as well as promoted apoptosis in SW480 and SW620 cells. More importantly, miR-342-5p and miR-608 significantly decreased the tumorigenic capacity of SW480 and SW620 cells in a mouse xenograft model. We also observed an inverse correlation between the expression of NAA10 and that of both miRNAs. Our results implicate miR-342-5p and miR-608 in colon cancer development and unveil the underlying mechanism of this phenomenon, which involves NAA10.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [U0932603]
第一作者机构：[1]The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Hongju,Li Qian,Niu Jie,et al.microRNA-342-5p and miR-608 inhibit colon cancer tumorigenesis by targeting NAA10[J].ONCOTARGET.2016,7(3):2709-2720.doi:10.18632/oncotarget.6458.
APA：
Yang, Hongju,Li, Qian,Niu, Jie,Li, Bai,Jiang, Dejun...&Bai, Song.(2016).microRNA-342-5p and miR-608 inhibit colon cancer tumorigenesis by targeting NAA10.ONCOTARGET,7,(3)
MLA：
Yang, Hongju,et al."microRNA-342-5p and miR-608 inhibit colon cancer tumorigenesis by targeting NAA10".ONCOTARGET 7..3(2016):2709-2720
