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Electroacupuncture in the repair of spinal cord injury: inhibiting the Notch signaling pathway and promoting neural stem cell proliferation

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C

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机构： [1]Second Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China

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关键词： nerve regeneration spinal cord electroacupuncture therapy neural stem cells notch signaling pathway astrocytes inflammation survival curve proliferation differentiation real-time quantitative PCR western blot assay neural regeneration

摘要：

Electroacupuncture for the treatment of spinal cord injury has a good clinical curative effect, but the underlying mechanism is unclear. In our experiments, the spinal cord of adult Sprague-Dawley rats was clamped for 60 seconds. Dazhui (GV14) and Mingmen (GV4) acupoints of rats were subjected to electroacupuncture: Enzyme-linked immunosorbent assay revealed that the expression of serum inflammatory factors was apparently downregulated in rat models of spinal cord injury after electroacupuncture. Hematoxylin-eosin staining and immunohistochemistry results demonstrated that electroacupuncture contributed to the proliferation of neural stem cells in rat injured spinal cord, and suppressed their differentiation into astrocytes. Real-time quantitative PCR and western blot assays showed that electroacupuncture inhibited activation of the Notch signaling pathway induced by spinal cord injury. These findings indicate that electroacupuncture repaired the injured spinal cord by suppressing the Notch signaling pathway and promoting the proliferation of endogenous neural stem cells.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区细胞生物学 4 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区细胞生物学 3 区神经科学

JCR分区：

出版当年[2015]版：

Q4 NEUROSCIENCES Q4 CELL BIOLOGY

最新[2023]版：

Q1 NEUROSCIENCES Q2 CELL BIOLOGY

影响因子： 5.9 最新[2023版] 5.2 最新五年平均 0.968 出版当年[2015版] 0.504 出版当年五年平均 0.22 出版前一年[2014版] 1.769 出版后一年[2016版]

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第一作者机构： [1]Second Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China

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