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Pituitary adenylate cyclase-activating polypeptide protects against beta-amyloid toxicity

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收录情况： ◇ SCIE

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机构： [a]Department of Neurology, Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Dignity Health Organization, Phoenix, AZ, USA [b]Department of Neurosurgery, The First Hospital of Kunming Medical University, Kunmming, China [c]Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA [d]Banner Alzheimer’s Institute, Phoenix, AZ, USA

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关键词： Alzheimer's disease PACAP SIRT3 Mitochondrial respiration

摘要：

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophin. However, its role in human Alzheimer's disease (AD) is largely unknown. We examined PACAP expression in postmortem human AD and triple transgenic mouse (3xTG, Psen1/APPSwe/TauP301L) brains. We established an in vitro model of primary neuronal cell culture to study the protective effects of PACAP against beta-amyloid (A beta) toxicity. We further studied the PACAP-Sirtuin 3 (Sirt3) pathway on mitochondrial function. PACAP expression was reduced in AD and 3xTG mouse brains. This reduction was inversely correlated with A beta and tau protein levels. Treatment with PACAP effectively protected neurons against A beta toxicity. PACAP stimulated mitochondrial Sirt3 production. Similar to PACAP, Sirt3 was reduced in AD and 3xTG brains. Knocking down Sirt3 compromised the neuroprotective effects of PACAP, and this was reversed by over-expressing Sirt3. PACAP is reduced in AD and may represent a novel therapeutic strategy. (C) 2014 Elsevier Inc. All rights reserved.

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出版当年[2015]版：

大类 | 2 区医学

小类 | 1 区老年医学 2 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区老年医学 3 区神经科学

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出版当年[2014]版：

Q1 GERIATRICS & GERONTOLOGY Q1 NEUROSCIENCES

最新[2023]版：

Q2 GERIATRICS & GERONTOLOGY Q2 NEUROSCIENCES

影响因子： 3.7 最新[2023版] 4.1 最新五年平均 5.013 出版当年[2014版] 5.224 出版当年五年平均 4.853 出版前一年[2013版] 5.153 出版后一年[2015版]

第一作者：

第一作者机构： [a]Department of Neurology, Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Dignity Health Organization, Phoenix, AZ, USA [*1]Department of Neurology, NRC428, Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Dignity Health Organization, 350 W. Thomas Road, Phoenix, AZ 85013, USA.

通讯作者：

通讯机构： [*1]Department of Neurology, NRC428, Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Dignity Health Organization, 350 W. Thomas Road, Phoenix, AZ 85013, USA.

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