机构：[1]Medical School of Kunming University, Kunming, P. R. China, 650118.昆明医科大学附属第一医院[2]The First Affiliated Hospital of Kunming Medical University, Kunming, P. R. China, 650032.昆明医科大学附属第一医院[3]Department of Rource Biology, Southwest Forestry University, Kunming, P. R. China, 650224.[4]The Affiliated Hospital of Guiyang Medical University, Guiyang, P. R. China, 550001
Glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH) is a disabling bone disease and it affects a lot of patients in the world widely. To investigate the effect of pravastatin on the early stage of GC-induced ONFH, white rabbits were injected twice with lipopolysaccharide (LPS) at 10 ug/kg each and three times with methyprednisolone (MPS) at 20 mg/kg each to the constructed ONFH model. The model groups were randomly divided into groups B and C. Group C was treated with pravastatin from the 5th week. Six rabbits in each group were tested; the blood lipids of 4, 8, 12 and 16 weeks. The rabbits were sacrificed at the 8, 12 and 16 weeks after the blood test. Both histopathologic and molecular studies were performed. The blood lipids levels of cholesterol (CHOL), triglyceride (TG) and high-density lipoprotein (HDL) changed significantly in the model group. After the continuously treatment of pravastatin, the blood lipids levels recovered significantly in group C were compared with those of group B. Necrosis was reduced and new bone repair increased; the repair of ONFH was enhanced in group C. The results suggested that, pravastatin was useful to treat the GC-induced ONFH in the early stage.
基金：
The investigation was funded by the National Natural
Science Foundation of China (No. 30860389, Principal
Investigator: Hong-bin Zhao; No. 81060361, Principal
Investigator: Min Hu), the Natural Science Foundation of
Yunnan Province of China (No. 2010C212 and
2010ZC169, Principal Investigator: Min Hu) and the
Natural Science Foundation of Kunming (No. 10S090202,
Principal Investigator: Min Hu).
第一作者机构：[1]Medical School of Kunming University, Kunming, P. R. China, 650118.
通讯作者：
推荐引用方式(GB/T 7714)：
Min Hu,Hong-bin Zhao,Jin-fang Meng,et al.Pravastatin enchances the osteogenic process to the glucocorticoid-induced osteonecrosis of the femoral head[J].AFRICAN JOURNAL OF BIOTECHNOLOGY.2011,10(38):7330-7341.
APA：
Min Hu,Hong-bin Zhao,Jin-fang Meng,Zhi-peng Yu,Hong-hui Xu...&Wei Tang.(2011).Pravastatin enchances the osteogenic process to the glucocorticoid-induced osteonecrosis of the femoral head.AFRICAN JOURNAL OF BIOTECHNOLOGY,10,(38)
MLA：
Min Hu,et al."Pravastatin enchances the osteogenic process to the glucocorticoid-induced osteonecrosis of the femoral head".AFRICAN JOURNAL OF BIOTECHNOLOGY 10..38(2011):7330-7341
