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The effects of vascular endothelial growth factor and microvessel density in the fibromyoma uteri

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机构： [a]Department of Pathology, Matermal and Child Health Hospital of Kunming, Kunming 650031, China [b]Department of Gynecology, Matermal and Child Health Hospital of Kunming, Kunming 650031, China [c]Department of Pathology, The First Affiliated Hospital of Kunming Medical College, Kunming 650031, China

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关键词： Fibromyoma uteri Microvessel density (MVD) Mifepristone Vascular endothelial growth factor (VEGF)

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Objective: To investigate vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) on the fibromyoma uteri treated with mifepristone. Methods: VEGF expression and MVD were counted on 60 cases of the fibromyoma uteri by SP method, including 40 cases of mifepristone treated and 20 cases of untreated patients as controlled group. Results: VEGF positive expression rate and MVD in treated group were 37.5% and 9.90 ± 5.95, which were lower than those in controlled group (80% and 16.36 ± 2.07; P < 0.05). Meanwhile, in treated group, those in marked shrink in tumor size sub-group were lower than in not obvious sub-group (12.0% and 7.89 ± 4.36 vs. 80% and 11.29 ± 3.10; P < 0.05). Conclusion: VEGF and MVD expression decreases in the fibromyoma uteri after treatment with mifepristone, suggesting that mifepristone could inhibit angiogenesis and blood supply resulting in tumor shrink. © Springer-Verlag Berlin Heidelberg 2008.

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第一作者机构： [a]Department of Pathology, Matermal and Child Health Hospital of Kunming, Kunming 650031, China

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