机构:[1]Key Laboratory of Animal Models and Human Disease, Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China[2]Graduate School of the Chinese Academy of Sciences, Beijing 100039, China[3]Department of Hematology, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan 650032, China内科科室血液内科昆明医科大学附属第一医院云南省第一人民医院[4]Department of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China
Caspase-8 (CASP8) involved in apoptosis plays an important role in mediating the normal regulation of cell proliferation, differentiation, inflammation, and homeostasis of multicellular organisms. Genetic polymorphisms, rs3834129 (-/CTTACT) and rs3769821 (T/C), in the promoter region of different CASP8 transcripts, were reported to be associated with genetic susceptibility of multiple cancers and non-Hodgkin's lymphoma (NHL), respectively. To investigate whether these two genetic variants, together with rs113686495 (-/CTGTCATT) which is 50 bp downstream of rs3769821, were associated with NHL in Chinese patients, we genotyped two cohorts of case and control samples from Kunming (case n = 64, control n = 133) and Shanghai (case n = 75, control n = 107). Luciferase assays were further performed to characterize the potential role of different alleles in the promoter region of the CASP8 gene. In contrast to previous studies, we found no difference regarding the genotypes and haplotypes of rs3834129, rs3769821, and rs113686495 between the case and control samples. Luciferase assays of the promoter regions harboring different alleles of these three variants also showed no difference. Our negative results gave no support for an active role for these genetic variants in conferring NHL in Chinese patients.
基金:
This study was supported by the National Natural Science
Foundation of China (30925021), Yunnan Province (2009CI119), and
the Chinese Academy of Sciences.
第一作者机构:[1]Key Laboratory of Animal Models and Human Disease, Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China[2]Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
通讯作者:
推荐引用方式(GB/T 7714):
Mei-Sheng Xiao,Deng-Feng Zhang,Yun Zeng,et al.Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients[J].ANNALS OF HEMATOLOGY.2011,90(10):1137-1144.doi:10.1007/s00277-011-1265-5.
APA:
Mei-Sheng Xiao,Deng-Feng Zhang,Yun Zeng,Yun-Feng Cheng&Yong-Gang Yao.(2011).Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients.ANNALS OF HEMATOLOGY,90,(10)
MLA:
Mei-Sheng Xiao,et al."Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients".ANNALS OF HEMATOLOGY 90..10(2011):1137-1144