机构：[1]Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China[2]Nanhua Hospital, University of South China, Hengyang, China[3]Department of Dermatology, The First Affiliated Hospital of Kunming Medical College, Kunming, China内科科室皮肤科昆明医科大学附属第一医院[4]Department of Dermatology, The First Hospital Of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Oxidative stress is one of the most important causes of the cellular senescence process. Previous studies showed that beta-catenin can regulate FoxO3a and this association was enhanced in cells exposed to oxidative stress. It has also been reported that beta-catenin can regulate some senescence-related proteins. We propose that beta-catenin may play a crucial role in senescence of normal human primary skin fibroblasts (NHSFs). Here, we explored the roles and mechanisms of beta-catenin on H(2)O(2)-induced senescence in NHSFs. beta-catenin expression was decreased in NHSFs after H(2)O(2) treatment. Overexpression of beta-catenin in NHSFs led to a marked delay of many senescent phenotypes induced by H(2)O(2). Furthermore, overexpression of beta-catenin in NHSFs can antagonise the alteration of reactive oxygen species accumulation and some senescence-related proteins expression induced by H(2)O(2) treatment. Our data demonstrated that beta-catenin can protect NHSFs from H(2)O(2)-induced premature senescence by alleviating oxidative stress and regulating some senescence-related molecules.
基金：
This study was supported by the grants from the National Natural Science
Foundation of China (NO. 30800992), the Specialised Research Fund for
the Doctoral Program of Higher Education (20100162110035), the Natural
Science Foundation of Hunan Province (NO. 10JJ9018), the Scientific
Research Fund of Hunan Provincial Science and Technology Department
(NO. 2010FJ3155), the Science Foundation of China Dermatologist
Association-P&G (NO. 2010CDA-P&G04) and the Key Scientific Research
Foundation of Nanhua Hospital, University of South China (NO.
10nyz01).
第一作者机构：[1]Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
推荐引用方式(GB/T 7714)：
Li-ming Tian,Hong-fu Xie,Xiao Xiao,et al.Study on the roles of beta-catenin in hydrogen peroxide-induced senescence in human skin fibroblasts[J].EXPERIMENTAL DERMATOLOGY.2011,20(10):836-838.doi:10.1111/j.1600-0625.2011.01324.x.
APA：
Li-ming Tian,Hong-fu Xie,Xiao Xiao,Ting Yang,Yao-hua Hu...&Ji Li.(2011).Study on the roles of beta-catenin in hydrogen peroxide-induced senescence in human skin fibroblasts.EXPERIMENTAL DERMATOLOGY,20,(10)
MLA：
Li-ming Tian,et al."Study on the roles of beta-catenin in hydrogen peroxide-induced senescence in human skin fibroblasts".EXPERIMENTAL DERMATOLOGY 20..10(2011):836-838
