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A new method of duplication of the chronic intraocular hypertension model: underwater electrocoagulation

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机构： [1]Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China [2]Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical College, Kunming 650031, Yunnan Province, China

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关键词： glaucoma intraocular hypertension animal model

摘要：

AIM: To study the experimental method of inducing the chronic intraocular hypertension in rat eyes. METHODS: Twenty Wistar rats were randomly divided into ocular hypertension and sham control groups. Intraocular pressure (IOP) was raised by electrocoagulating at least 3 episcleral and limbal veins on the right eye of each rat in ocular hypertension group and its contralateral eye was used as control. At 1, 2, 3, 4 and 8 week after the electrocoagulation of the veins, TOP were measured. RESULTS: The treatment of electrocoagulation caused a significant TOP increase of the right eyes over the baseline, over the contralateral eyes, and over the sham control eyes (repeated measures ANOVA, P<0.001). At 1 week, IOP was 30.12+/-5.18mmHg, and maintained the high TOP up to 8 weeks. CONCLUSION: The chronic intraocular hypertension model could be successfully created by electrocoagulating three or more episcleral and limbal veins.

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最新[2023]版：

大类 | 4 区医学

小类 | 4 区眼科学

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出版当年[2008]版：

无

最新[2023]版：

Q2 OPHTHALMOLOGY

影响因子： 1.9 最新[2023版] 1.8 最新五年平均 0 出版当年[2008版] 0 出版当年五年平均 0 出版前一年[2007版]

第一作者：

第一作者机构： [1]Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China [*1]Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China

通讯作者：

通讯机构： [*1]Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China

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