详情页 - 昆明医科大学第一附属医院知识库

当前位置：首页 > 详情页

Involvement of microRNAs in diabetes and its complications

文献详情

资源类型：

WOS体系：

Pubmed体系：

作者：

机构： [a]Department of Endocrinology, First Affiliated Hospital, Kunming Medical University, 295 Xichang Rd., Wuhua Qu, Kunming, Yunnan 650031, China [b]School of Computing, University of South Alabama, Mobile, AL 36688, United States

出处：

DOI：

ISSN：

关键词： Diabetes Diabetic complications Glucose homeostasis Insulin Insulin resistance MicroRNA

摘要：

Diabetes is a severe condition worldwide. It is characterized by chronic hyperglycemia and is caused by defects in insulin production, secretion, and action. Both genetic and environmental factors contribute to the development of type 1 and type 2 diabetes. The pathogenesis of diabetes is complex and the underlying molecular mechanisms are only partially understood. MicroRNAs (miRNAs) play a fundamental role in diabetes and its complications. This chapter focuses on the dysregulation of miRNAs involved in the regulation of pancreatic islet insulin production and secretion as well as action and signaling in peripheral tissues. The roles of miRNAs in the development of diabetic complications are also discussed. Modulating miRNA expression, by either upregulation or inhibition, holds a promise as a strategy for treating this metabolic disease. © Springer Science+Business Media LLC 2017.

语种：

被引次数：

WOS：

PubmedID：

第一作者：

第一作者机构： [a]Department of Endocrinology, First Affiliated Hospital, Kunming Medical University, 295 Xichang Rd., Wuhua Qu, Kunming, Yunnan 650031, China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Determinants and correlates of adipose tissue insulin resistance index in Japanese women without diabetes and obesity [2]Effect of Insulin-Regulated FOXC2 Expression in Adipocyte Differentiation and Insulin Resistance. [3]细胞因子在胰岛素抵抗中的作用 [4]EGCG与胰岛素抵抗 [5]心肌胰岛素抵抗微 RNA机制研究进展 [6]Associations of adipose insulin resistance index with pancreatic β cell function (inverse) and glucose excursion (positive) in young Japanese women [7]心肌胰岛素抵抗微 RNA机制研究进展 [8]Gas6与2型糖尿病及其并发症的研究进展 [9]MicroRNA在代谢综合征疾病中的研究进展 [10]Insulin resistance is associated with Sfrp5 in obstructive sleep apnea