Aim: To evaluate the efficacy of combination of acitretin and UVB versus UVB alone in treatment of moderate to severe plaque psoriasis. Methods: This comparative study was conducted at Department of Dermatology & Venereology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032 from January 2016 to June 2016. Total 80 patients suffering from plaque psoriasis having age from 15 years to 50 years either male or female were selected for this study. Results: Total 80 patients with moderate to server plaque psoriasis were included in this study. Mean age of the patients of Group A was 32.82 ± 11.084 years and mean age of the patients of Group B was 33.00 ± 11.200 years. Efficacy of the treatment was noted in 33 (82.5%) patients of Group A and 22 (55%) patients of Group B. Significant (P = 0.015) difference was found in efficacy of both groups. No association of efficacy of drugs was found with gender and age. Conclusion: In present study two groups of patients with plaque psoriasis were treated with combination of UVB and Acitretine and UVB alone. Results of this study showed a significant difference between the efficacy of two treatment groups. But insignificant association of efficacy was seen with gender and age.