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Long-term performance of the second-generation cobaltchromium sirolimus-eluting stents in real-world clinical practice: 3-year clinical outcomes from the prospective multicenter FOCUS registry

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机构: [a]Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China [b]Zhongshan Hospital of Fudan University, China [c]Fuwai Cardiovascular Hospital, China [d]Beijing Anzhen Hospital, China [e]Xi'an Xijing Hospital, China [f]Tianjin Chest Hospital, China [g]Shanghai Tenth People's Hospital, China [h]The People's Hospital of Liaoning Province, China [i]Putuo District Certral Hospital of Shanghai, China [j]Shanghai Chest Hospital, China [k]The First Affiliated Hospital of Dalian Medical University, China [l]Guangdong General Hospital, China [m]People's Liberation Army General Hospital, China [n]The Affiliated Hospital of Medical College of Qingdao University, China [o]Chengdu Military General Hospital, China [p]Meizhou people's hospital, China [q]The First Affiliated Hospital of Medical College of Xi'an Jiaotong University, China [r]The First People's Hospital of Jining City, China [s]Jiangxi Provincial People's Hospital, China [t]General Hospital of Fushun Mining Group, China [u]Shanxi Provincial Institute of Cardiovascular Disease, China [v]The Second Hospital of Jilin University, China [w]Cangzhou Central Hospital, China [x]Xiangya Hospital of Zhongnan University, China [y]Shanghai Changhai Hospital, China [z]Xingtai Cardiovascular Disease Hospital, China [aa]Sir Run Run Shaw Hospital of Zhejiang University, China [ab]The People's Hospital of Shanxi Province, China [ac]The Second Clinical College of Harbin Medical University, China [ad]Armed Police Medical College Hospital, China [ae]Beijing Chaoyang Hospital, China [af]People's Hospital of Peking University, China [ag]Beijing Shijitan Hospital, China [ah]Daqing Oil Field General Hospital, China [ai]Shengjing Hospital of China Medical University, China [aj]Nanjing Drum Tower Hospital, China [ak]Huashan Hospital of Fudan University, China [al]Shanghai Sixth People's Hospital, China [am]Shanghai Xinhua Hospital, China [an]The Second Affiliated Hospital of Zhejiang University, China [ao]Hangzhou First People's Hospital, China [ap]Nanjing First Hospital, China [aq]Xuzhou Centre Hospital, China [ar]Affiliated Hospital of Guangdong Medical College, China [as]Weifang Yidu Zhongxin Hospital, China [at]The First Affiliated Hopital of Lanzhou University, China [au]The Second Affiliated Hospital of Kunming Medical College, China [av]Wuhan Tongji Hospital of Huazhong University of Science and Technology, China [aw]Wuhan University Renmin Hospital, China [ax]Xiangfan City Central Hospital, China [ay]Wuhan Asia Heart Hospital, China [az]First People's Hospital of Yulin City, China [ba]Beijing Luhe Hospital, China [bb]The First Affiliated Hospital of Sun yatsen University, China [bc]Zhujiang Hospital, China [bd]The First Clinical College of Harbin Medical University, China [be]The people's hospital of Guangxi Zhuang Autonomous Region, China [bf]Shanghai Renji Hospital, China [bg]The Third Hospital of Peking University, China [bh]The first Affiliated Hospital of China Medical University, China [bi]Affiliated Hospital of Jiangsu University, China [bj]Yantai Yuhuangding Hospital, China [bk]Qilu Hospital of Shandong University, China [bl]Xiangtan Central Hospital, China [bm]Shanghai Huadong Hospital, China [bn]Shandong Provincial Hospital, China [bo]The First Affiliated Hospital of Kunming Medical College, China [bp]Fujian Medical University Union Hospital, China [bq]Tongji Hospital of Tongji University, China [br]Tianjin First Central Hospital, China [bs]The Fourth Clinical College of Harbin Medical University, China [bt]The Second Affiliated Hospital of Dalian Medical University, China [bu]Zhongshan Hospital of Xiamen University, China [bv]The First People's Hospital of Ningbo City, China [bw]Affiliated Hospital of Weifang Medical College, China [bx]Guangzhou Nanfang Hospital, Southern Medical University, China [by]Wuhan Union Hospital, China [bz]The Fourth Affiliated Hospital of China Medical University, China [ca]Dalian 210 Hospital, China [cb]The First Affiliated Hospital of Chongqing Medical University, China [cc]Shanghai Minhang District Certral Hospital, China [cd]Siriraj Hospital of Mahidol University, Bangkok, Thailand [ce]Bina Waluya Cardiac Hospital, Indonesia [cf]Medistra Hospital, Indonesia
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关键词: Cobalt-chromium Coronary artery disease Sirolimus-eluting stent (SES)

摘要:
Background: The short- and mid-term outcomes of the second-generation cobalt-chromium sirolimuseluting stent (CoCr-SES) in real-world patients had been reported previously, but the long-term performance remained unclear. The objective of this analysis was to evaluate the long-term safety and efficacy of the second-generation CoCr-SES from the FOCUS registry. Methods: The FOCUS registry (ClinicalTrials.gov Identifier: NCT00868829) enrolled all-comers eligible to receive Firebird-2 CoCr-SES. Follow-up was continued to 3 years to evaluate long-term safety and effectiveness of the second-generation CoCr-SES in real-world practice. Results of the extended-use group and standard-use group are compared to explore performance of CoCr-SES in more severe patients with more complex lesions. Results: The rate of 3-year MACE was 7.37%, consisting of 84 cases (1.78%) of cardiac death, 166 cases (3.52%) of MI and 98 cases (2.08%) of TVR. ARC definite/probable stent thrombosis happened in 34 (0.72%) patients, only 3 new cases (< 0.1%) of very late stent thrombosis was reported in the third year. Meanwhile, the difference of MACE (7.77% vs. 6.06%; P=0.058), TLF (4.71% vs. 3.49%; P=0.085) and ARC definite/probable stent thrombosis (0.83% vs. 0.37%; P=0.116) between extended-use group and standard-use group showed no significance. Conclusions: The second-generation CoCr-SES was associated with continued low rates of 3-year MACE, TLF and stent thrombosis in a broad spectrum of patients. © Journal of Thoracic Disease.

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出版当年[2017]版:
大类 | 4 区 医学
小类 | 4 区 呼吸系统
最新[2023]版:
大类 | 3 区 医学
小类 | 4 区 呼吸系统
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第一作者机构: [a]Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
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