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Sphingosine kinase 1/sphingosine 1-phosphate signalling pathway as a potential therapeutic target of pulmonary hypertension

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机构： [1]First Department of Respiratory Medicine, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China [2]First Department of Respiratory Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

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关键词： Endothelial dysfunction Pulmonary hypertension Pulmonary vascular remodeling Sphingosine 1-phosphate Vascular smooth muscle cell

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Pulmonary hypertension is characterized by extensive vascular remodelling, leading to increased pulmonary vascular resistance and eventual death due to right heart failure. The pathogenesis of pulmonary hypertension involves vascular endothelial dysfunction and disordered vascular smooth muscle cell (VSMC) proliferation and migration, but the exact processes remain unknown. Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid involved in a wide spectrum of biological processes. S1P has been shown to regulate VSMC proliferation and migration and vascular tension via a family of five S1P G-protein-coupled receptors (S1P1-SIP5). S1P has been shown to have both a vasoconstrictive and vasodilating effect. The S1P receptors S1P1 and S1P3 promote, while S1P2 inhibits VSMC proliferation and migration in vitro in response to S1P. Moreover, it has been reported recently that sphingosine kinase 1 and S1P2 inhibitors might be useful therapeutic agents in the treatment of empirical pulmonary hypertension. The sphingosine kinase 1/S1P signalling pathways may play a role in the pathogenesis of pulmonary hypertension. Modulation of this pathway may offer novel therapeutic strategies. © 2015, E-Century Publishing Corporation. All rights reserved.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

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第一作者：

第一作者机构： [1]First Department of Respiratory Medicine, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China

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通讯机构： [1]First Department of Respiratory Medicine, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China [2]First Department of Respiratory Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China [*1]First Department of Respiratory Medicine, Yan’an Hos-pital Affiliated to Kunming Medical University, No. 245, East Renmin Road, Kunming 650051, Yun-nan, China. [*2]First Department of Respiratory Medicine, First Affiliated Hospital of Kunming Medical University, No. 295, West Xichang Road, Kunming 650032, Yunnan, China.

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