机构：[a]Department of Neurology, The First People's Hospital of Yunnan, Kunhua Affiliated Hospital of Kunming Medical University, Kunming 650032, China[b]Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China
Depression is a highly debilitating and widely distributed illness in the general population. Geranylgeranylacetone (GGA), a non-toxic anti-ulcer drug, has been reported to have protective effects in the central nervous system. The aim of this study was to determine the antidepressant effect of GGA in a chronic mild stress (CMS) model of depression. We confirmed that CMS in rats caused a reduction in locomotor activity and an increase in the levels of monoamine oxidase-A (MAO-A) and caspase-3 in the hippocampus. GGA treatment reversed stress-induced alterations in locomotor activity and target levels of MAO-A and caspase-3. In addition, GGA treatment induced heat shock protein 70 (Hsp70) expression in the hippocampus. These findings suggest that GGA possesses an antidepressant activity in a CMS model of depression. The activity of GGA in the relief of depression may be mediated via the induction of Hsp70 expression to suppress MAO-A expression and the apoptosis cascade.
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外文
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中科院(CAS)分区：
出版当年[2013]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[a]Department of Neurology, The First People's Hospital of Yunnan, Kunhua Affiliated Hospital of Kunming Medical University, Kunming 650032, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhong J.-M,Wu S.-Y,Bai J,et al.Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism(Open Access)[J].Experimental and therapeutic medicine.2012,4(4):627-632.doi:10.3892/etm.2012.669.
APA：
Zhong, J.-M,Wu, S.-Y,Bai, J,Guo, Q,Tao, J...&Fu, H.(2012).Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism(Open Access).Experimental and therapeutic medicine,4,(4)
MLA：
Zhong, J.-M,et al."Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism(Open Access)".Experimental and therapeutic medicine 4..4(2012):627-632
