机构：[1]Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan province 650032, PR China.外科科室麻醉手术科（医技）昆明医科大学附属第一医院[2]Department of Anesthesiology, The Fourth Affiliated Hospital of Kunming Medical University, The Second People's Hospital of Yunnan, Kunming, Yunnan province 650021, PR China.
Diabetic cardiovascular diseases (DCVDs) are the most common complications of diabetes mellitus and are considered to be one of the most important threats to global health and an economic burden. Long noncoding RNA (lncRNA), circular RNA (circRNA), and miRNA are a novel group of noncoding RNAs that are involved in the regulation of various pathophysiological processes, including DCVDs. Interestingly, both lncRNA and circRNA can act as competing endogenous RNA of miRNA, thereby regulating the expression of the target mRNA by decoying or sponging the miRNA. In this review, we focus on the mechanistic, pathological and functional roles of lncRNA/circRNA-miRNA-mRNA networks in DCVDs and further discuss the potential implications for early detection, therapeutic intervention and prognostic evaluation.
基金：
This research was funded by the National Natural Science Foundation of China (grant numbers 81860050, 81460044 and
81160035), Yunnan Health Training Project of High Levels Talents (L-2018007), Yunnan Provincial Science and Technology Department
(grant number 2017FE468-039), Health and Family Planning Commission of Yunnan Province (grant number 2018NS0126),
Program for Innovative Research Team of Kunming Medical University (grant number CXTD201802), Yunnan Provincial Ten
Thousand-Talent Program-Famous Doctor (grant number YNWR-MY-2018-043), Yunnan Provincial Education Department (grant
number 2020Y0120) and Innovative Fund of Kunming Medical University (grant number 2020D013).
第一作者机构：[1]Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan province 650032, PR China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan province 650032, PR China.
推荐引用方式(GB/T 7714)：
Xiong Wei,Yao Mengran,Yang Yuqiao,et al.Implication of regulatory networks of long noncoding RNA/circular RNA-miRNA-mRNA in diabetic cardiovascular diseases[J].EPIGENOMICS.2020,12(21):1929-1947.doi:10.2217/epi-2020-0188.
APA：
Xiong Wei,Yao Mengran,Yang Yuqiao,Qu Yan&Qian Jinqiao.(2020).Implication of regulatory networks of long noncoding RNA/circular RNA-miRNA-mRNA in diabetic cardiovascular diseases.EPIGENOMICS,12,(21)
MLA：
Xiong Wei,et al."Implication of regulatory networks of long noncoding RNA/circular RNA-miRNA-mRNA in diabetic cardiovascular diseases".EPIGENOMICS 12..21(2020):1929-1947
