机构：[1]Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.广东省人民医院[2]The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.[3]Zhongshan Ophthalmic Center, SunYat-Sen University, Guangzhou, Guangdong, China.[4]Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.外科科室眼科昆明医科大学附属第一医院[5]Department of Medical Ultrasound, Guangzhou First People's Hospital, Guangzhou, China.[6]School of Medicine, South China University of Technology, Guangzhou, China.
Inflammation is known to be involved in the progression of diabetic retinopathy. Follicular helper T cells (Tfh) play critical roles in the differentiation of long-live plasma cells and production of antibodies, whereas circulating CD4+CXCR5+ T cells may act as a counterpart to measure Tfh cell disorders. In this study, we investigated whether Tfh could be involved in the development of diabetic retinopathy (DR) by assessing circulating Tfh cells in peripheral blood. Data showed that serum levels of total IgG and IgA were both significantly increased in type 2 diabetes mellitus (T2DM) patients with proliferative diabetic retinopathy (PDR) than with non-PDR. Also, B cell activation and differentiation were both enhanced in T2DM patients with PDR. Little changes were detected in levels of Th1, Th2, and Th17 cells. As indicated by elevated serum levels and supernatant from cultured PBMC of IL-21, we found increased circulating Tfh cells in PDR patients with dysregulated subsets. This study suggests the involvement of circulating Tfh cells in DR and, in particular, the pathogenesis of PDR.
基金：
National Natural Science
Foundation of China (grant 81870663 to Honghua Yu, grant 81760175
to Ling Yuan), the Science and Technology Program of Guangzhou
(grant 202002030074 to Honghua Yu), and the Medical Science
Technology Program of Guangdong Province (grant B2020099 to
Suihong Ma).
第一作者机构：[1]Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.[2]The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.[3]Zhongshan Ophthalmic Center, SunYat-Sen University, Guangzhou, Guangdong, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yu Honghua,Liu Baoyi,Wu Guanrong,et al.Dysregulation of circulating follicular helper T cells in type 2 diabetic patients with diabetic retinopathy.[J].IMMUNOLOGIC RESEARCH.2021,69(2):153-161.doi:10.1007/s12026-021-09182-8.
APA：
Yu Honghua,Liu Baoyi,Wu Guanrong,Du Zijing,Wu Qiaowei...&Li Tao.(2021).Dysregulation of circulating follicular helper T cells in type 2 diabetic patients with diabetic retinopathy..IMMUNOLOGIC RESEARCH,69,(2)
MLA：
Yu Honghua,et al."Dysregulation of circulating follicular helper T cells in type 2 diabetic patients with diabetic retinopathy.".IMMUNOLOGIC RESEARCH 69..2(2021):153-161
