Pyropotosis is a pro-inflammatory programmed pattern of cell death which mainly depends on caspase-1, which is characterized by the rapid membrane rupture and the release of pro-inflammatory intracellular contents. Inflammatory bowel disease is a chronic intestinal inflammation caused by unknown etiology, which may be associated with the changes of intestinal epithelial barrier function, symbiotic microorganisms, diet and the immune system. At present, many studies have demonstrated the effect of apoptosis and autophagy on IBD, and pyropotosis has been confirmed to exist in IBD probablely, which is different from the apoptosis and autophagy but has close relation with the two. This article reviews the association between pyropotosis and IBD. © 2021 Chinese Medical Association