机构：[1]Yunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center,Kunming 650301, China[2]Department of Dermatology and Venereology, FirstAffiliated Hospital of Kunming Medical University, Kunming 650032, China[3]College of Pharmaceutical Sciences, Yunnan University of TraditionalChinese Medicine, Kunming 650500, China
Antiphospholipid syndrome (APS) is a non-inflammatory autoimmune disorder induced by antiphospholipid antibodies, which occurs exceedingly rarely in pediatric population and even more rarely reported in HIV positive children. A case of 11 years old boy had a sudden onset of swelling in his left lower leg along with pain which were worsening gradually. Initially, topical ointment was applied for 1 month which were ineffective in reducing pain and swelling. Instead, the symptoms were aggravated and suddenly spread to the proximal thigh, accompanied by dyskinesia of left lower leg. Both color doppler ultrasonography and vascular CT scan of left lower leg revealed deep venous thrombosis. His serum anti-phospholipid antibodies (aPLs) were tested positive. He was a known case of HIV virological failure with substantial HIV viral load (VL) despite receiving regular antiretroviral therapy (ART). His symptoms improved after giving aggressive antithrombotic and high dose corticosteroid treatments.
When pediatric patients develop thrombotic disease, APS also needs to be ruled out. The autoantibodies levels should be routinely tested to look for recurrent thrombosis in children with HIV/AIDS.
基金：
the Foundation of Scientific research
Project of Yunnan Province education Department, China (2018JS251),
Medical reserve personnel training plan of Yunnan Provincial Health
Commission, China (H-2018104), the National Natural Science Foundation of
China (81660737 and 81860553), The Joint Special Fund of Science and
Technology Department of Yunnan Province-Yunnan University of Chinese
Medicine (2017FF117–003).
第一作者机构：[1]Yunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center,Kunming 650301, China[2]Department of Dermatology and Venereology, FirstAffiliated Hospital of Kunming Medical University, Kunming 650032, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Dong Rong-Jing,Lei Su-Yun,Li Jun,et al.Thrombotic antiphospholipid syndrome in a child with human immunodeficiency virus: a rare case report.[J].THROMBOSIS JOURNAL.2021,19(1):doi:10.1186/s12959-021-00273-y.
APA：
Dong Rong-Jing,Lei Su-Yun,Li Jun,Yang Xin-Ping,Li Yu-Ye&Zhang Yun-Gui.(2021).Thrombotic antiphospholipid syndrome in a child with human immunodeficiency virus: a rare case report..THROMBOSIS JOURNAL,19,(1)
MLA：
Dong Rong-Jing,et al."Thrombotic antiphospholipid syndrome in a child with human immunodeficiency virus: a rare case report.".THROMBOSIS JOURNAL 19..1(2021)
