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RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6

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收录情况： ◇ SCIE

作者：
Wang, H[a,b] * ; Yang, C[a,b] ; Li, Y[a,b] ; Zhao, S[c] ; Ma, P[a] ; Mao, B[a,d,*1] ;
机构： [a]State Key Laboratory of Genetic and Resources, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, 650223, China [b]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650223, China [c]Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China [d]Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China
出处：
DOI： 10.1016/j.bbrc.2021.03.156
ISSN：

关键词： Aggresome Autophagy HDAC6 RNF220 Shh/Gli signaling

摘要：
Sonic hedgehog acts as a key mitogen to drive cell proliferation and as a morphogen to direct cell differentiation during embryonic development and adult tissue maintenance by controlling the activities of its transcriptional effectors Glis. We previously reported that RNF220 controls the nuclear translocation and subcellular localization of Glis by promoting their K63-linked polyubiquitination, through which it fine tunes Shh/Gli gradients during ventral spinal cord patterning. RNF220 also epigenetically regulates Shh signaling by targeting epifactor EED in cerebellar development. Here, we continued to study the molecular events underlying RNF220-mediated Shh regulation in the cytoplasm. The results showed that HDAC6 is required for RNF220-induced Gli accumulation in the cytoskeletal fraction and inclusion in aggresomes. In the cytoplasm, Glis polyubiquitinated by RNF220 are prone to interact with p62 and destined for autophagy-mediated degradation. Additionally, we showed that RNF220 inhibits the processing of Gli2 and Gli3 both in vitro and in vivo. Collectively, our studies shed new light on Shh signaling regulation. © 2021 Elsevier Inc.

基金：
This work was supported by the National Natural Science Foundation of China ( 31671521 and 31871483 to B.M., 82060292 to S.Z.), and the open project of State Key Laboratory of Genetic Resources and Evolution ( GREKF20-07 to S.Z.). P.M. was supported by the Youth Innovation Promotion Association of Chinese Academy of Sciences .
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
JCR分区：
出版当年[2021]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [a]State Key Laboratory of Genetic and Resources, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, 650223, China [b]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650223, China
通讯作者：
通讯机构： [a]State Key Laboratory of Genetic and Resources, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, 650223, China [d]Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China [*1]State Key Laboratory of Genetic and Resources, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, 650223, China
推荐引用方式(GB/T 7714)：
Wang H,Yang C,Li Y,et al.RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2021,557:323-328.doi:10.1016/j.bbrc.2021.03.156.
APA：
Wang, H,Yang, C,Li, Y,Zhao, S,Ma, P&Mao, B.(2021).RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,557,
MLA：
Wang, H,et al."RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 557.(2021):323-328

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