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SH3BGRL3, transcribed by STAT3, facilitates glioblastoma tumorigenesis by activating STAT3 signaling

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收录情况： ◇ SCIE

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机构： [a]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China [b]Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China [c]Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, 266071, China

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关键词： Glioblastoma GSCs SH3BGRL3 STAT3 Targeted therapy

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Glioblastoma (GBM) is the most aggressive tumors of the central nervous system. Here, we report that SH3 binding glutamic acid-rich protein like 3 (SH3BGRL3) was extremely highly expressed in GBM and glioma stem cells. SH3BGRL3 high expression associates with worse survival of GBM patients. Functionally, Targeting SH3BGRL3 obviously impairs GSCs self-renewal in vitro. Most importantly, we first report that SH3BGRL3 is a direct transcriptional target gene of signal transducer and activator of transcription 3 (STAT3) and thereby activating STAT3 signaling in turn. Additionally, forced expression of the constitutively activated STAT3 (STAT3-C) rescued GSCs self-renewal inhibited by SH3BGRL3 silencing. Collectively, we first identified a critical positive feedback loop between SH3BGRL3 and STAT3, which facilitates the tumorigenic potential of GBM. © 2021

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出版当年[2022]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

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出版当年[2021]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 3.322 出版当年[2021版] 3.498 出版当年五年平均 3.575 出版前一年[2020版] 3.1 出版后一年[2022版]

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第一作者机构： [a]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China

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