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SH2B3, Transcribed by STAT1, Promotes Glioblastoma Progression Through Transducing IL-6/gp130 Signaling to Activate STAT3 Signaling.

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收录情况： ◇ SCIE

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机构： [1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, China

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关键词： SH2B3 STAT1 STAT3 glioblastoma glioblastoma stem cell

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Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. The aberrant activation of STAT3 commonly occurs in GBM and is a key player in GBM tumorigenesis. Yet, the aberrant activation of STAT3 signaling is not fully understood. Here, we report that SH2B adaptor protein 3 (SH2B3) is highly expressed in GBM and preferentially expressed in GBM stem cells (GSCs). Moreover, SH2B3 high expression predicts worse survival of GBM patients. Targeting SH2B3 considerably impairs GBM cell proliferation, migration, and GSCs' self-renewal in vitro as well as xenograft tumors growth in vivo. Additionally, we provide evidence suggesting that STAT1 directly binds to the promoter of SH2B3 and activates SH2B3 expression in the transcriptional level. Functionally, SH2B3 facilitates GBM progression via physically interacting with gp130 and acting as an adaptor protein to transduce IL-6/gp130/STAT3 signaling. Together, our work firstly uncovers that the STAT1/SH2B3/gp130/STAT3 signaling axis plays critical roles in promoting GBM progression and provides insight into new prognosis marker and therapeutic target in GBM. Copyright © 2021 Cai, Lu, Wang, Shi, Yuan and Wang.

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出版当年[2022]版：

大类 | 2 区生物学

小类 | 2 区发育生物学 3 区细胞生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 2 区发育生物学 3 区细胞生物学

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出版当年[2021]版：

Q1 DEVELOPMENTAL BIOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q1 DEVELOPMENTAL BIOLOGY Q2 CELL BIOLOGY

影响因子： 4.6 最新[2023版] 5.2 最新五年平均 6.081 出版当年[2021版] 6.576 出版当年五年平均 6.684 出版前一年[2020版] 5.5 出版后一年[2022版]

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第一作者机构： [1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, China

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