机构：[1]Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China首都医科大学附属安贞医院[2]Department of Cardiovascular Surgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China心脏大血管外科(心脏外科)昆明医科大学附属第一医院[3]Department of Animal Zoology, Kunming Medical University, Kunming 650032, Yunnan, China[4]Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China外科科室麻醉手术科（医技）昆明医科大学附属第一医院[5]Department of Cardiology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China内科科室心脏内科昆明医科大学附属第一医院
The morbidity and mortality of myocardial ischemia-reperfusion injury (MIRI) have increased in modern society. Noncoding RNAs (ncRNAs), including lncRNAs, circRNAs, piRNAs and miRNAs, have been reported in a variety of studies to be involved in pathological initiation and developments of MIRI. Hence this review focuses on the current research regarding these ncRNAs in MIRI. We comprehensively introduce the important features of lncRNAs, circRNAs, piRNA and miRNAs and then summarize the published studies of ncRNAs in MIRI. A clarification of lncRNA-miRNA-mRNA, lncRNA-transcription factor-mRNA and circRNA-miRNA-mRNA axes in MIRI follows, to further elucidate the crucial roles of ncRNAs in MIRI. Bioinformatics analysis has revealed the biological correlation of mRNAs with MIRI. We provide a comprehensive perspective for the roles of these ncRNAs and their related networks in MIRI, providing a theoretical basis for preclinical and clinical studies on ncRNA-based gene therapy for MIRI treatment.
基金：
This study was supported by Beijing Natural Science Foundation (grant no.: 7202038) and Beijing municipal administration of
hospitals clinical medicine development of special funding support (grant no.: ZYLX201503). This work was also supported by the
Yunnan Province Education Department (grant no.: 2021J0230) and Yunnan Provincial Science and Technology Department (grant
no.: 2019FE001[-045]).
第一作者机构：[1]Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China[2]Department of Cardiovascular Surgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Xiang-feng Bai,Rui-ze Niu,Jia Liu,et al.Roles of noncoding RNAs in the initiation and progression of myocardial ischemia-reperfusion injury.[J].EPIGENOMICS.2021,13(09):715-743.doi:10.2217/epi-2020-0359.
APA：
Xiang-feng Bai,Rui-ze Niu,Jia Liu,Xu-dong Pan,Feng Wang...&Li-zhong Sun.(2021).Roles of noncoding RNAs in the initiation and progression of myocardial ischemia-reperfusion injury..EPIGENOMICS,13,(09)
MLA：
Xiang-feng Bai,et al."Roles of noncoding RNAs in the initiation and progression of myocardial ischemia-reperfusion injury.".EPIGENOMICS 13..09(2021):715-743
