机构：[1]Department of Anesthesiology, The First People’s Hospital of Yunnan Province, Kunming 650032, China云南省第一人民医院[2]Laser Medical Center, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 JinBi Road, Kunming, China云南省第一人民医院[3]The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China云南省第一人民医院[4]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China[5]Medical school, Kunming University of Science and Technology, Kunming 650500, China
Osteoporosis (OP) is a multifactorial bone disease that occurs worldwide. The treatment of OP is still unsatisfactory. Bone mesenchymal stem cell (BMSC) differentiation is a key process in OP pathogenesis. Low-level laser irradiation (LLLI) has been reported to regulate BMSC proliferation, but the role of circRNAs in the LLLI-based promotion of BMSC proliferation remains unclear. CircRNAs are essential molecular regulators that participate in numerous biological processes and have therapeutic potential. miR-124-3p is an essential microRNA (miRNA), and its expression changes are related to BMSC proliferation ability. In the present study, gain-loss function of experiments demonstrated that circRNA_0001052 could regulate the proliferation of BMSCs by acting as a miR-124-3p sponge through the Wnt4/beta-catenin pathway. The results of this study strongly suggest that circRNA_0001052 plays an essential role in BMSC proliferation in response to LLLI treatment, which is a potential therapeutic manipulation with clinical applications.
基金：
National Key Research and Development Project [2017YFB0403801, 2018YFB0407201]; Joint Special Program of Yunnan Province Department and Kunming Medical University for applied basic research [2019FE001(-111)]; Application base project of Yunnan Science and Technology Department [2019FB097]; Yunnan health training project of high level talent [D-2018005]
第一作者机构：[1]Department of Anesthesiology, The First People’s Hospital of Yunnan Province, Kunming 650032, China[2]Laser Medical Center, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 JinBi Road, Kunming, China[3]The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Anesthesiology, The First People’s Hospital of Yunnan Province, Kunming 650032, China[2]Laser Medical Center, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 JinBi Road, Kunming, China[5]Medical school, Kunming University of Science and Technology, Kunming 650500, China
推荐引用方式(GB/T 7714)：
Liu Na,Lu Weiwei,Qu Xiaowen,et al.LLLI promotes BMSC proliferation through circRNA_0001052/miR-124-3p[J].LASERS IN MEDICAL SCIENCE.2022,37(2):849-856.doi:10.1007/s10103-021-03322-0.
APA：
Liu, Na,Lu, Weiwei,Qu, Xiaowen&Zhu, Chongtao.(2022).LLLI promotes BMSC proliferation through circRNA_0001052/miR-124-3p.LASERS IN MEDICAL SCIENCE,37,(2)
MLA：
Liu, Na,et al."LLLI promotes BMSC proliferation through circRNA_0001052/miR-124-3p".LASERS IN MEDICAL SCIENCE 37..2(2022):849-856
