机构：[1]Department of Neurological Surgery, 1st Affiliated Hospital of KunmingMedical University, Kunming, China[2]Yunnan Key Laboratory of LaboratoryMedicine, Yunnan Engineering Technology Center of Digestive disease, 1stAffiliated Hospital of Kunming Medical University, Kunming, China昆明医科大学附属第一医院[3]GeneticDiagnosis Center, Kunming City Maternal and Child Health Hospital,Kunming, China
Background:Dysregulation of microRNAs (miRNAs) plays a critical role during the occurrence and progress of pituitary adenomas (PAs).However,the roles of miRNAs in the invasiveness of PA are poorly understood.This study aims to more comprehensively and specific define the relationship between altered miRNA and PA invasion.Methods:The differential expression of miRNAs (DEMs) between invasive PAs (IPAs) and non-invasive PAs (NPAs)was explored by RNA sequencing and which functions were analyzed by gene ontology (GO) as well as Kyoto Encyclopedia of Genes and Genomes (KEGG).The miRNA-mRNA network was predicted with bioinformatics.Results:We identified 31 upregulated miRNAs and 24 downregulated miRNAs in IPAs compared with NPAs.GO analysis and KEGG pathway analysis showed the DEMs were mainly associated with cell proliferation and cell cycle pathway.In addition,on the count of predicted miRNA-mRNA network,two hub miRNAs were identified.Conclusions:Our results demonstrate the miRNA-mRNA network in detail,which suggest that miRNA may be a promising target in diagnosis and therapy for IPAs.
基金：
the Applied Basic Research Foundation of
Yunnan Province, the Research Innovation Team of Yunnan Province, the
Medical Academic Leader Training Program of Yunnan Province, and the
Outstanding Youth Scientists and Technicians Training Program of Yunnan
Province.
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]Department of Neurological Surgery, 1st Affiliated Hospital of KunmingMedical University, Kunming, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurological Surgery, 1st Affiliated Hospital of KunmingMedical University, Kunming, China
推荐引用方式(GB/T 7714)：
Chao Zhang,Yuan Qian,Yisheng Qiao,et al.Analysis of whole genome-wide microRNA transcriptome profiling in invasive pituitary adenomas and non-invasive pituitary adenomas[J].Chinese Neurosurgical Journal.2019,5(4):27.doi:10.1186/s41016-019-0177-4.
APA：
Chao Zhang,Yuan Qian,Yisheng Qiao,Yao Li,Wei Wang...&Xingli Deng.(2019).Analysis of whole genome-wide microRNA transcriptome profiling in invasive pituitary adenomas and non-invasive pituitary adenomas.Chinese Neurosurgical Journal,5,(4)
MLA：
Chao Zhang,et al."Analysis of whole genome-wide microRNA transcriptome profiling in invasive pituitary adenomas and non-invasive pituitary adenomas".Chinese Neurosurgical Journal 5..4(2019):27
