First, to analyze the risk factors of hyperglycemia in Growth hormone-secreting pituitary adenoma(GHPA) by comparing clinical data, biochemical indexes, and imaging data. Second, to study the correlation between growth hormone receptor (GHR) gene polymorphism and hyperglycemia. The results of this study will help to evaluate the GHPA condition and choose effective treatment measures, reduce the GHPA clinical mortality and improve the prognosis of GHPA. From January 2014 to July 2020, we collected 120 patients 18-75 years old who were diagnosed with GHPA in the First Affiliated Hospital of Kunming Medical University. According to blood glucose levels, they were divided into hyperglycemia as the study group and normal blood glucose as a control group. The course of the disease, BMI, FPG, GH, HOMA-IR, and PBG was with statistically significant differences in hyperglycemia patients(P < 0.05).However,gender,age,PRL,The size of the tumor volume,HOMA-β,0'INS,120'INS,0'C-P,120'C-P,IGF-1 and HbA1c were with statistically significant differences(P > 0.05)compared with control group.In the study, The risk factors associated with hyperglycemia in GHPA were the course of the disease, BMI, GH, and FPG.In the study group, FPG was positively correlated with the size of the tumor volume and GH.PBG was positively correlated with FPG and HOMA-IR and negatively correlated with HOMA-β.In the subgroup analysis of the study group, FPG was with statistically significant differences (P=0.049). The results showed that FPG between the microadenoma group and the giant adenoma group was with statistically significant differences (P=0.019). However, PBG wasn't with statistically significant differences (P=0.133).In the present study, when we performed correlation analysis of risk factors and GHR genotype polymorphisms, we found that d3/d3GHR was significantly associated with BMI compared to f1/d3GHR (P=0.049), and d3/d3GHR explained 29.44% of the variation in BMI values;d3/d3GHR had a lower BMI value of 4.83kg/ m2.d3/d3GHR was not significantly correlated with GH (P=0.965), FPG (P=0.625), and the course of disease (P=0.755) compared to f1/d3GHR.