机构：[1]Department of Vascular Surgery, the First Affiliated Hospital, Kunming Medical University, Kunming, China外科科室普通外科普通外三科(血管外科)昆明医科大学附属第一医院[2]Department of Palliative Medicine, Yunnan Cancer Hospital, the Third Affiliated Hospital of Kunming Medical University, Kunming, China
To explore the possible single nucleotide polymorphisms (SNPs) sites in the promoter region of fibrinogen B beta (FGB), and construct logistic regression model and haplotype model, so as to reveal the influence of FGB promoter SNPs on susceptibility, hemodynamics and coagulation function of lower extremity deep venous thrombosis (LEDVT) in the genetic background. LEDVT patients (120) and healthy people (120) were taken as case and control objects, respectively. SNPs and their genotypes of FGB promoter were detected by promoter sequencing and PCR-RFLP. The parameters of coagulation system were evaluated. There were 6 SNPs in FGB promoter, which were beta-148C/T, beta-249C/T, beta-455G/A, beta-854G/A, beta-993C/T and beta-1420G/A. The genotype and allele frequency of beta-1420 G/A, beta-455G/A, beta-249c/T and beta-148C/T were significantly different between the LEDVT group and the control group, but not beta-993C/T and beta-854G/A. In addition, we found that the higher the content of Fibrinogen (FG), the higher the risk of LEDVT. The risk of LEDVT increased by 4.579 times for every unit increase of fibrinogen. We also found that FG, PT and APTT in LEDVT group were higher than those in control group, while TT was lower than those in control group; Furthermore, there was no significant difference in all coagulation indexes among 6 SNP genotypes in LEDVT group, while a significant difference was found between the 2 genotypes of beta-993C/T in the control group. beta-993C/T may indirectly affect the susceptibility of LEDVT by improving the basic level of plasma FG.
基金：
Foundation of Applied Basic Research Program of Yunnan Province (Kunming, China) [2019FE001(-216)]
第一作者机构：[1]Department of Vascular Surgery, the First Affiliated Hospital, Kunming Medical University, Kunming, China
通讯作者：
通讯机构：[2]Department of Palliative Medicine, Yunnan Cancer Hospital, the Third Affiliated Hospital of Kunming Medical University, Kunming, China[*1]Li Zhuang, Department of Palliative Medicine, Yunnan Cancer Hospital, the Third Affiliated Hospital of Kunming Medical University, #519 Kunzhou Road, Xishan District, Kunming, Yunnan 650118, China.
推荐引用方式(GB/T 7714)：
Han Shengbin,Yang Bin,Feng Yaoyu,et al.The Correlation Between FGB Promoter Polymorphism and Clotting Function in Patients With Idiopathic Lower Extremity Deep Venous Thrombosis[J].CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS.2021,27:doi:10.1177/1076029620967108.
APA：
Han, Shengbin,Yang, Bin,Feng, Yaoyu,Zhao, Lingfeng,Feng, Qun...&Zhuang, Li.(2021).The Correlation Between FGB Promoter Polymorphism and Clotting Function in Patients With Idiopathic Lower Extremity Deep Venous Thrombosis.CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS,27,
MLA：
Han, Shengbin,et al."The Correlation Between FGB Promoter Polymorphism and Clotting Function in Patients With Idiopathic Lower Extremity Deep Venous Thrombosis".CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 27.(2021)
