Objective: A prospective experiment was designed to explore all possible SNPs in the promoter region of fibrinogen B beta (FGB) and reveal the influence of these SNPs on susceptibility of pulmonary embolism.Methods: In this 2-year randomized prospective study, we had totally recruited 203 volunteers. 58 PE patients (58 out of 145 VTE patients) and 114 healthy people were taken as case and control objects, respectively. FGB promoter was detected by gene sequencing.Results: There were 6 SNPs in FGB promoter, which were beta-1420G/A, beta-993C/T, beta-854G/A, beta-455G/A, beta-249C/T, and beta-148C/T. Genotype frequencies of individual SNPs between the cases and controls were not statistically significant, all p > .05. After excluding subjects of COVID-19 infection within 6 months, the statistical results (35 PE patients vs 66 healthy people) were consistent.Conclusion: The susceptibility to pulmonary embolism may not be affected by any SNP in the FGB promoter region.
基金：
We thank all the doctors, nurses, and students who participated in this study during these years.
第一作者机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Vasc Surg, Kunming, Peoples R China
通讯作者：
通讯机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Vasc Surg, Kunming, Peoples R China[*1]Kunming Med Univ, Affiliated Hosp 1, Dept Vasc Surg, 295 Xichang Rd, Kunming 650032, Peoples R China
推荐引用方式(GB/T 7714)：
Chen Wenxiang,Han Shengbin,Xu Jingzhe,et al.Fibrinogen B β promoter polymorphism may not be associated with pulmonary embolism[J].PHLEBOLOGY.2024,39(3):174-182.doi:10.1177/02683555231216915.
APA：
Chen, Wenxiang,Han, Shengbin,Xu, Jingzhe,Ding, Shun&Guan, Hongxi.(2024).Fibrinogen B β promoter polymorphism may not be associated with pulmonary embolism.PHLEBOLOGY,39,(3)
MLA：
Chen, Wenxiang,et al."Fibrinogen B β promoter polymorphism may not be associated with pulmonary embolism".PHLEBOLOGY 39..3(2024):174-182
