Coronavirus disease 2019 (COVID-19) is a highly infectious epidemic disease that has seriously affected human health worldwide. To date, however, there is still no definitive drug for the treatment of COVID-19. Cell-based therapies could represent a new breakthrough. Over the past several decades, mesenchymal stromal cells (MSCs) have proven to be ideal candidates for the treatment of many viral infectious diseases due to their immunomodulatory and tissue repair or regeneration promoting properties, and several relevant clinical trials for the treatment of COVID-19 have been registered internationally. Herein, we systematically summarize the clinical efficacy of MSCs in the treatment of COVID-19 based on published results, including mortality, time to symptom improvement, computed tomography (CT) imaging, cytokines, and safety, while elaborating on the possible mechanisms underpinning the effects of MSCs, to provide a reference for subsequent studies.
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出版当年[2023]版:
大类|2 区医学
小类|2 区细胞与组织工程2 区细胞生物学2 区医学:研究与实验
最新[2023]版:
大类|2 区医学
小类|2 区细胞与组织工程2 区细胞生物学2 区医学:研究与实验
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出版当年[2022]版:
Q1CELL & TISSUE ENGINEERINGQ1CELL BIOLOGYQ1MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q1CELL & TISSUE ENGINEERINGQ1CELL BIOLOGYQ1MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构:[1]First Naval Hosp Southern Theater Command, Dept Neurosurg, Zhanjiang 524000, Peoples R China
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推荐引用方式(GB/T 7714):
Lu Kun,Shi-tao Geng,Tang Shikai,et al.Clinical efficacy and mechanism of mesenchymal stromal cells in treatment of COVID-19[J].STEM CELL RESEARCH & THERAPY.2022,13(1):doi:10.1186/s13287-022-02743-0.
APA:
Lu, Kun,Shi-tao Geng,Tang, Shikai,Yang, Hua,Xiong, Wei...&Wang, Songqing.(2022).Clinical efficacy and mechanism of mesenchymal stromal cells in treatment of COVID-19.STEM CELL RESEARCH & THERAPY,13,(1)
MLA:
Lu, Kun,et al."Clinical efficacy and mechanism of mesenchymal stromal cells in treatment of COVID-19".STEM CELL RESEARCH & THERAPY 13..1(2022)