机构：[1]Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, China[2]Key Laboratory of Chemistry in Ethnic Medicinal Resources & Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming, Yunnan 650504, China[3]Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650500, China内科科室皮肤科昆明医科大学附属第一医院
Although amphibian-derived bioactive peptides have attracted increasing attention for their potential use in the treatment of photodamage, research is still in its infancy. In this study, we obtained a new antioxidant peptide, named OA-GI13 (GIWAPWPPRAGLC), from the skin of the odorous frog Odorrana andersonii and determined its effects on ultraviolet B (UVB)-induced skin photodamage as well as its possible molecular mechanisms. Results showed that OA-GI13 directly scavenged free radicals, maintained the viability of hydrogen peroxide-challenged keratinocytes, promoted the release of superoxide dismutase, catalase, and glutathione, and reduced the level of lactate dehydrogenase. Furthermore, topical application of OA-GI13 in mice alleviated dorsal skin erythema and edema and protected the skin against UVB irradiation by increasing antioxidant levels and decreasing peroxide, malondialdehyde, and 8-hydroxydeoxyguanosine levels. OA-GI13 also alleviated oxidative stress injury in vivo and in vitro, possibly by inhibiting p38 protein phosphorylation. Our study confirmed the anti-photodamage effects of this novel amphibian-derived peptide, thus providing a new molecule for the development of drugs and topical agents for the treatment of skin photodamage.
基金：
National Natural Science
Foundation of China (81760648, 32060212, and 81860253), Project of
Yunnan Applied Basic Research-Kunming Medical University Union
Foundation (202101AY070001–006 and 202101AY070001–042,
2019FE001(-020)), Yunnan Applied Basic Research Project Foundation
(2019FB128), Program for Innovative Research Team in Ministry of
Education of China (IRT17-R49), and Science and Technology Leadership
Talent Project in Yunnan China (2017HA010).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|2 区医学
小类|1 区药学2 区医学：研究与实验
最新[2023]版：
大类|2 区医学
小类|1 区药学2 区医学：研究与实验
JCR分区：
出版当年[2022]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, China[2]Key Laboratory of Chemistry in Ethnic Medicinal Resources & Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming, Yunnan 650504, China[3]Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650500, China[*1]Key Laboratory of Chemistry in Ethnic Medicinal Resources & Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, China.[*2]Department of Dermatology, First Affiliated Hospital of Kunming Medical University, China.[*3]Faculty of Basic Medical Science, Kunming Medical University, China.
推荐引用方式(GB/T 7714)：
Wang Siyu,Yang Meifeng,Yin Saige,et al.A new peptide originated from amphibian skin alleviates the ultraviolet B-induced skin photodamage[J].BIOMEDICINE & PHARMACOTHERAPY.2022,150:doi:10.1016/j.biopha.2022.112987.
APA：
Wang, Siyu,Yang, Meifeng,Yin, Saige,Zhang, Yingxuan,Zhang, Yue...&Yang, Xinwang.(2022).A new peptide originated from amphibian skin alleviates the ultraviolet B-induced skin photodamage.BIOMEDICINE & PHARMACOTHERAPY,150,
MLA：
Wang, Siyu,et al."A new peptide originated from amphibian skin alleviates the ultraviolet B-induced skin photodamage".BIOMEDICINE & PHARMACOTHERAPY 150.(2022)
医学