Malnutrition is common in hemodialysis patients and is linked to increased morbidity and mortality. Anthropometric measurements, biochemical parameters, and the modified quantitative subjective global assessment (MQSGA) were used in this study to assess the effects of nutritional support in maintenance hemodialysis patients. This prospective cohort study included 62 patients (32 males, 30 females; mean age: 49.81 +/- 13.86 years) who were randomly divided into two groups according to full nutritional assistance (group 1) and partial nutritional assistance (group 2) that were followed from September 2020 to September 2021. The patient's anthropometric measurements, MQSGA score, and biochemical parameters were assessed at the 1st and 12th months of hemodialysis. After a year of maintenance hemodialysis with full nutritional support and partial nutritional support; Body mass index (BMI), triceps skinfold thickness (TSFT), mid-arm circumference (MAC), and handgrip strength (HGS) were all measured, and the mid-arm muscle circumference (MAMC) was determined. Several biochemical parameters were assessed, including Serum albumin (ALB), serum calcium, serum phosphorus, parathyroid hormone (iPTH), hemoglobin (HGB), triglycerides (TG), serum iron (Fe), and low-density lipoprotein (LDL). The MQSGA score correlated positively with MIS (r = 0.618, P: 0.001) whereas albumin (r = -0.282, P: 0.027), grip strength (r = -0.376, P: 0.003), dry weight (r = -0.275, P: 0.030) all had negative correlations with the MQSGA score. After one year of treatment, In group 1, iPTH, BMI, MQSGA Score, and MIS decreased whereas handgrip strength, dry body weight, albumin, Kt/Vurea, MAMC, TC, and Hb increased, The difference (P<0.05) was statistically significant. After treatment in group 2, MAMC, MAC, Hb, and Grip strength all decreased, while TC increased; the difference was statistically significant (P<0.05). The findings suggest that providing complete nutritional assistance can significantly improve overall nutritional status, reducing malnutrition in hemodialysis patients. Thus, nutritional status in hemodialysis patients can be assessed using the MQSGA score and anthropometric measurements.