机构：[1]School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products, Kunming Medical University, Kunming 650500, Yunnan, P. R. China,[2]West China Hospital, Sichuan University, Chengdu 610044, China四川大学华西医院[3]Departments of Sports Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P. R. China外科科室运动医学科昆明医科大学附属第一医院[4]School of Pharmacy, Naval Medical University, Shanghai 200433, China
Three new xanthone compounds, 1,3,5-trihydroxy-2-(2-hydroxy-3-methylbut-3-enyl)-4-(3-methylbut-2-enyl)xanthone (1), toxyloxanthone E (2), dehydrocycloguanandin B (3) along with 15 known xanthones (4-18) were isolated from the aerial parts of Calophyllum polyanthum Wall. ex Choisy. Their structures were fully characterised using spectroscopic data, as well as comparison with the previous literature data. All isolated compounds had inhibitory effects against CYP1A1, CYP1A2 and CYP1B1 enzymes at working concentration of 10 mu M, 1 mu M and 10 mu M, respectively. Among them, compounds 10, 11, and 12 exhibited better CYP1A2 enzyme inhibitory effects than that of the positive control alpha-naphthoflavone, with 51.05 %, 56.82 % and 44.93 % inhibition, respectively.
基金：
Yunnan Provincial Science and
Technology Department (Nos. 2019HB025,
202005AE160004, 202005AF150043) and the National
Natural Science Foundation of China (31860087).
第一作者机构：[1]School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products, Kunming Medical University, Kunming 650500, Yunnan, P. R. China,
通讯作者：
推荐引用方式(GB/T 7714)：
Cao Ting-Ting,Huang Ruo-Yue,Li Xu,et al.Xanthones from Calophyllum Polyanthum Wallich ex Choisy with CYP1 Enzymes Inhibitory Activity[J].CHEMISTRY & BIODIVERSITY.2022,19(6):doi:10.1002/cbdv.202200268.
APA：
Cao, Ting-Ting,Huang, Ruo-Yue,Li, Xu,Yang, Teng-Yun,Xie, Hui-Ding...&Li, Xian.(2022).Xanthones from Calophyllum Polyanthum Wallich ex Choisy with CYP1 Enzymes Inhibitory Activity.CHEMISTRY & BIODIVERSITY,19,(6)
MLA：
Cao, Ting-Ting,et al."Xanthones from Calophyllum Polyanthum Wallich ex Choisy with CYP1 Enzymes Inhibitory Activity".CHEMISTRY & BIODIVERSITY 19..6(2022)
