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Systemic inflammation-based predictors of pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients.

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收录情况： ◇ SCIE

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机构： [1]Department of Oncology, The First Affiliated Hospital of Kunming Medical University, Kunming, China

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关键词： Hematological parameters locally advanced rectal cancer neoadjuvant chemoradiotherapy pathological tumor response systemic inflammation‑based predictors

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To investigate whether systemic inflammation-based predictors can predict tumor response to neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC).Totally, 205 LARC patients undergoing neoadjuvant CRT and curative surgery between 2008 and 2017 were analyzed. After propensity score matching, 132 patients were included in the study. Hematological parameters were collected, and their relationship with tumor response was investigated.After propensity score matching, patients in good response group before CRT displayed significantly lower neutrophil-lymphocyte-ratio (NLR) and platelet-lymphocyte-ratio (PLR) than those in poor response group, while there were no significant differences in all hematological characteristics between the two groups after CRT. The cutoff values of pre-CRT NLR and pre-CRT PLR after receiver operating characteristic analysis were 3.10 and 198.7, respectively. Multivariate analysis revealed that while there was no association between pre-CRT PLR and tumor response, pre-CRT NLR ≥3.1 was identified as the predictor of poor tumor response (P = 0.007).An increased NLR before CRT can serve as a hematological factor for predicting a poor tumor response in LARC.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2022]版：

Q4 ONCOLOGY

最新[2023]版：

Q4 ONCOLOGY

影响因子： 1.4 最新[2023版] 1.3 最新五年平均 1.3 出版当年[2022版] 1.5 出版当年五年平均 1.331 出版前一年[2021版] 1.4 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Oncology, The First Affiliated Hospital of Kunming Medical University, Kunming, China

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通讯机构： [1]Department of Oncology, The First Affiliated Hospital of Kunming Medical University, Kunming, China [*1]Department of Oncology, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Kunming 650032, China.

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