机构：[1]Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032医学检验科医技科室[2]Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410000[3]Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650118[4]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223[5]Department of Thoracic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032胸外科外科科室[6]Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Zhaotong, Zhaotong, Yunnan 657000[7]Department of Nuclear Medicine, The Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650021, P.R. China
Lung cancer has a high mortality rate worldwide.
Non‑SMC condensin I complex subunit H (NCA PH) has been
identified to be one of the regulatory subunits of the condensin I
complex, which is essential for the correct packaging and segregation
of chromosomes in eukaryotes. NCAPH is abnormally
overexpressed in various types of cancer. A pro‑survival member
of the Bcl‑2 family, myeloid cell leukemia sequence 1 (Mcl‑1) is
also frequently overexpressed in multiple cancers and is associated
with poorer clinical outcomes for patients. The association
of NCAPH and Mcl‑1 proteins with the clinical and pathological
features of non‑small cell lung cancer (NSCLC) remains to
be elucidated. In the current study, the positive percentage of
NCA PH in the non‑cancerous lung tissues was revealed to be
higher compared with that in NSCLC . However, the positive
percentage of Mcl‑1 in the non‑cancerous lung tissues was lower
compared with NSCLC . In addition, NCA PH high‑expression
patients had a higher overall survival rate compared with patients
exhibiting low expression, whereas the Mcl‑1 high‑expression
group had a lower survival rate. Pairwise association in 260 cases
of NSCLC revealed that overexpression of the NCAPH protein
was negatively associated with Mcl‑1 expression and vice versa.
The results of multivariate Cox proportional hazard regression
analysis also indicated that NCA PH and Mcl‑1 demonstrated
potential as distinct prognostic factors that may be used in
NSCLC. The expression of NCAPH and Mcl‑1 may be associated
with, and act as distinct molecular marks for the prediction of a
poor prognosis in patients with NSCLC .
基金：
Yunnan Provincial
Department of science and Technology‑Kunming Medical
University applied basic research joint project in 2019 (grant
no. 2019FE001 (‑042)) and Scientific research projects of
research institutions in medical and health units of Yunnan
Province in 2018 (grant no. 2018NS0111).
第一作者机构：[1]Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
QIUXIA XIONG,SONGQING FAN,LINCAN DUAN,et al.NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer[J].MOLECUL AR MEDICINE REPORTS.2020,22(4):2916-2924.doi:10.3892/mmr.2020.11359.
APA：
QIUXIA XIONG,SONGQING FAN,LINCAN DUAN,BAIYANG LIU,XIULIN JIANG...&YONG DUAN.(2020).NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer.MOLECUL AR MEDICINE REPORTS,22,(4)
MLA：
QIUXIA XIONG,et al."NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer".MOLECUL AR MEDICINE REPORTS 22..4(2020):2916-2924
