ObjectiveTo study changes in blood brain barrier (BBB) permeability in systemic lupus erythematosus (SLE) patients, and explore the association between the alterations in BBB permeability and depression/anxiety in SLE. MethodsBrain dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) images were collected from 42 SLE patients and 23 healthy controls (HCs). Based on the Patlak pharmacokinetic model, the K-trans value of each voxel in the whole brain of each subject was calculated. BBB permeability indicator (the K-trans value) between SLE patients and healthy control group was compared. Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to assess the mental health of SLE patients. The difference in BBB permeability was compared on SLE patients with depression/anxiety, SLE patients without depression/anxiety and HCs by ANOVA analysis. ResultsThe K-trans value of the right insular region of the SLE group was significantly higher than that of the healthy control group. And the K-trans value of the right insular region in SLE patients with depression/anxiety was significantly increased compared with SLE patients without depression/anxiety and HCs. ConclusionsSLE patients have increased BBB permeability, mainly in the right insular area. The increased BBB permeability in the right insular region is associated with the depression/anxiety in SLE patients.
基金：
National Natural Science Foundation of China [81760296, 82060259, 81460256]; Yunnan Province High-level health technical talents [L-2019004, L-2019011]; Yunnan Province Special Project for Famous Medical Talents of the Ten Thousand Talents Program [YNWR-MY-2018-040, YNWR-MY-2018-041]; Funding of Yunnan Provincial Health Science and Technology Plan [2017NS051, 2018NS0133]; Ministry of Science and Technology of Yunnan Province [2018ZF016]; Yunnan Province Clinical Research Center for Skin Immune Diseases [2019ZF012]; Yunnan Province Clinical Center for Skin Immune Diseases [ZX2019-03-02]
第一作者机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Kunming, Yunnan, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Kunming, Yunnan, Peoples R China[*1]Kunming Med Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Kunming, Yunnan, Peoples R China[2]Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming, Yunnan, Peoples R China[*2]Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming, Yunnan, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Xiangyu,Ma Lihua,Luo Yuli,et al.Increasing of Blood Brain Barrier Permeability and the Association With Depression and Anxiety in Systemic Lupus Erythematosus Patients[J].FRONTIERS IN MEDICINE.2022,9:852835.doi:10.3389/fmed.2022.852835.
APA：
Wang, Xiangyu,Ma, Lihua,Luo, Yuli,Yang, Yifan,Upreti, Bibhuti...&Xu, Jian.(2022).Increasing of Blood Brain Barrier Permeability and the Association With Depression and Anxiety in Systemic Lupus Erythematosus Patients.FRONTIERS IN MEDICINE,9,
MLA：
Wang, Xiangyu,et al."Increasing of Blood Brain Barrier Permeability and the Association With Depression and Anxiety in Systemic Lupus Erythematosus Patients".FRONTIERS IN MEDICINE 9.(2022)
