Augmentation of neurogenesis and migration of newly born neurons into ectopic regions like the hilus play critical roles during the pathophysiology of acute kindled seizures. Evidence shows that disrupted in schizophrenia 1 (DISC1) has an influence on adult neurogenesis in the dentate gyrus (DG); however, its role of regulating neurogenesis and mispositioned newborn neurons in the hilus after status epilepticus (SE) remains unknown. Using double immunofluorescence staining, the present study clarifies that DISC1 is co-expressed with nearly all of the neuronal markers, which are characterized by different stages of neuronal development, after pilocarpine-induced SE in mice. This reveals that DISC1 takes part in the modulation of neurogenesis in the hilus post-SE. Unexpectedly, an interesting phenomenon was observed as well. Some glial fibrillary acidic protein (GFAP)-positive cells in the hilus appeared to encircle the DISC1-positive cells, which possibly indicated that DISC1 may participate in the process of neuronal or neural development associated with astrocytes such as phagocytosis, dendritic spine development, synaptic transmission, and developmental and synaptic plasticity.(c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.
基金：
National Natural Science
Foundation of China (82160260, 81601134), the Yunnan
Health Training Project of High-Level Talents (H-
2018056, L-2019019), the Young and Middle-aged
Academic and Technical Leaders Reserve Talents
Project of Yunnan Province Science and Technology
Department (202105AC160041), and the Scientific
Research Fund Project of the Education Department of
Yunnan Province (2022Y218).
第一作者机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Neurol, 295 Xi Chang Rd, Kunming 650032, Yunnan, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Lu,Zhu Lin,Xu Jing,et al.Disrupted in Schizophrenia 1 Regulates Ectopic Neurogenesis in the Mouse Hilus After Pilocarpine-induced Status Epilepticus[J].NEUROSCIENCE.2022,494:69-81.doi:10.1016/j.neuroscience.2022.05.009.
APA：
Chen, Lu,Zhu, Lin,Xu, Jing,Xu, Puying,Han, Yanbing...&Wu, Qian.(2022).Disrupted in Schizophrenia 1 Regulates Ectopic Neurogenesis in the Mouse Hilus After Pilocarpine-induced Status Epilepticus.NEUROSCIENCE,494,
MLA：
Chen, Lu,et al."Disrupted in Schizophrenia 1 Regulates Ectopic Neurogenesis in the Mouse Hilus After Pilocarpine-induced Status Epilepticus".NEUROSCIENCE 494.(2022):69-81
