机构：[1]Cardiology Department, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China,内科科室心脏内科昆明医科大学附属第一医院[2]Cardiology Department, People’s Hospital of Chuxiong Yi Autonomous Prefecture, Chuxiong, Yunnan, China,[3]Yunnan Key Laboratory of Laboratory Medicine, Yunnan Institute of Experimental Diagnosis, Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University, Kunming, China.医技科室医学检验科昆明医科大学附属第一医院
Background: Due to the lack of evidence and inconsistency of sex differences in Heart failure (HF) in the Chinese population, this study aimed to compare sex differences in functional capacity and quality of life (QoL) between women and men after standard HF medications therapies, and analyze whether sex differences were associated with the composite endpoints of all-cause mortality or HF-related hospitalization and cardiac event-free survival rate in Chinese patients with HF. Methods: This was a 1-year longitudinal study. Participants included patients with HF from March 2017 to December 2018. At baseline and followed up at 1, 6, and 12 months later, functional capacity was assessed by 6-minute walk testing (6MWT), QoL was measured with the Kansas City Cardiomyopathy Questionnaire (KCCQ) and EuroQoL five dimensions (EQ-5D). The Cox proportional hazards model and Kaplan-Meier curves were used to determine sex differences in subsequent outcomes. The Cox proportional hazards model was used to identify the risk factors for composite endpoints. Kaplan-Meier curves were used to compare survival. Results: All patients were assigned to either men group (n = 94) or women group (n = 60). Longitudinal follow-ups showed a continuously increasing in 6MWT, Kansas City Cardiomyopathy Questionnaire overall score, EQ-5D visual analogue scale, and EQ-5D Index score in both groups (all P < 0.001); however, women reported a lower level of all parameters at the 1, 6, and 12 months follow-ups (all P < 0.05). In addition, women had a higher risk of all-cause mortality or HF-related hospitalization and a lower cardiac event-free survival rate than men (log-rank test, P = 0.027). Conclusion: Women reported worse functional capacity, QoL, and prognosis than men in a sample of Chinese patients with HF. Our findings highlight the importance of paying attention to sex differences in HF.
基金：
This work was supported by the Famous Doctor Special Project
of the Yunnan Health Training Project of High Level Talents (grant number
RLMY20190006); the Yunnan Health Training Project of High Level Talents
(grant number L-2019025); the Yunnan Health Training Project of High Level
Talents (grant number H-2019052); the Construction of Program of Clinical
Medical Center of Cardiovascular and Cerebrovascular Disease of Yunnan
Province (grant number ZX 2019-03-01); the Nature Science Foundation of
Yunnan Province (grant number 2018FE001-037); the Yunnan Health Training
Project of High Level Talents (grant number L-2018014); and the Scientific
Research Fund Project of Education Department of Yunnan Province (grant
number 2022J0229).
第一作者机构：[1]Cardiology Department, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China,
共同第一作者：
通讯作者：
通讯机构：[1]Cardiology Department, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China,[*1]Cardiology Department, the First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Kunming 650032, China
推荐引用方式(GB/T 7714)：
Ma Yiming,Shi Yunke,Ma Wenfang,et al.A prospective study on sex differences in functional capacity, quality of life and prognosis in patients with heart failure[J].MEDICINE.2022,101(26):doi:10.1097/MD.0000000000029795.
APA：
Ma, Yiming,Shi, Yunke,Ma, Wenfang,Yang, Dan,Hu, Zhao...&Cai, Hongyan.(2022).A prospective study on sex differences in functional capacity, quality of life and prognosis in patients with heart failure.MEDICINE,101,(26)
MLA：
Ma, Yiming,et al."A prospective study on sex differences in functional capacity, quality of life and prognosis in patients with heart failure".MEDICINE 101..26(2022)
