Objective: To analyze the relationships between quality of life (QOL) and socio-demographic and clinical characteristics of patients with pulmonary heart disease(CPHD), and to discuss the clinical significance of the QOL score changes. Methods: The survey was conducted in 141 CPDH patients who were in the acute exacerbation. Using the QLICD-CPHD (V2.0) which was a QOL scale for CPHD patients to detect the data. The data was assessed at the time of patients' admission and dischange to the hospital. The relationships between QOL and sociodemographic and clinical characteristics were analyzed by statistical methods. Results: QOL was negatively correlated with the alanine aminotransferase, the aspartate amino transferase, the urea, the blood platelet count, the PaCO 2 and the body temperature; and QOL was positively correlated with the total protein, the kalium, the leukocyte number, the neutrophil absolute value, the red blood cell count, the PO 2 and the lung functional parameters. Lung function was the influence factor of the QOL. The influence factors of the body function included FVC, FEV1, EV1/FVC and PEF; the influence factors of the psychological function included FEV1, EV1/FVC and PEF; the influence factors of the social function included PEF and FVC; the influence factors of the specific module included FVC, FEV1, EV1/FVC and PEF; the influence factors of the total scale scores included FVC, FEV1, PEF and EV1/FVC. The 95% confidence interval of QOL was analyzed by combinating with the lung functional classification, then the clinical significances were revealed when the minimal changes of scores were 5.25 in physical function, 3.27 in social function, 2.91 in psychological function, 7.62 in specific module and 10.85 in the overall. Conclusion: The change of QOL score can reflect the clinical degree and condition of CPHD patients.