机构：[1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore,[2]Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming, China,外科科室眼科昆明医科大学附属第一医院[3]Institute of High Performance Computing, Agency for Science, Technology and Research (A∗Star), Singapore, Singapore,[4]Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore,[5]Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore,[6]Department of Ophthalmology, The Second People’s Hospital of Yunnan Province, Kunming, China
PurposeTo develop a deep learning (DL) algorithm for predicting anterior chamber depth (ACD) from smartphone-acquired anterior segment photographs. MethodsFor algorithm development, we included 4,157 eyes from 2,084 Chinese primary school students (aged 11-15 years) from Mojiang Myopia Progression Study (MMPS). All participants had with ACD measurement measured with Lenstar (LS 900) and anterior segment photographs acquired from a smartphone (iPhone Xs), which was mounted on slit lamp and under diffuses lighting. The anterior segment photographs were randomly selected by person into training (80%, no. of eyes = 3,326) and testing (20%, no. of eyes = 831) dataset. We excluded participants with intraocular surgery history or pronounced corneal haze. A convolutional neural network was developed to predict ACD based on these anterior segment photographs. To determine the accuracy of our algorithm, we measured the mean absolute error (MAE) and coefficient of determination (R-2) were evaluated. Bland Altman plot was used to illustrate the agreement between DL-predicted and measured ACD values. ResultsIn the test set of 831 eyes, the mean measured ACD was 3.06 +/- 0.25 mm, and the mean DL-predicted ACD was 3.10 +/- 0.20 mm. The MAE was 0.16 +/- 0.13 mm, and R-2 was 0.40 between the predicted and measured ACD. The overall mean difference was -0.04 +/- 0.20 mm, with 95% limits of agreement ranging between -0.43 and 0.34 mm. The generated saliency maps showed that the algorithm mainly utilized central corneal region (i.e., the site where ACD is clinically measured typically) in making its prediction, providing further plausibility to the algorithm's prediction. ConclusionsWe developed a DL algorithm to estimate ACD based on smartphone-acquired anterior segment photographs. Upon further validation, our algorithm may be further refined for use as a ACD screening tool in rural localities where means of assessing ocular biometry is not readily available. This is particularly important in China where the risk of primary angle closure disease is high and often undetected.
第一作者机构：[1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore,[2]Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming, China,
通讯作者：
通讯机构：[1]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore,[4]Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore,[5]Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore,
推荐引用方式(GB/T 7714)：
Qian Chaoxu,Jiang Yixing,Soh Zhi Da,et al.Smartphone-Acquired Anterior Segment Images for Deep Learning Prediction of Anterior Chamber Depth: A Proof-of-Concept Study[J].FRONTIERS IN MEDICINE.2022,9:doi:10.3389/fmed.2022.912214.
APA：
Qian, Chaoxu,Jiang, Yixing,Soh, Zhi Da,Sakthi Selvam, Ganesan,Xiao, Shuyuan...&Cheng, Ching-Yu.(2022).Smartphone-Acquired Anterior Segment Images for Deep Learning Prediction of Anterior Chamber Depth: A Proof-of-Concept Study.FRONTIERS IN MEDICINE,9,
MLA：
Qian, Chaoxu,et al."Smartphone-Acquired Anterior Segment Images for Deep Learning Prediction of Anterior Chamber Depth: A Proof-of-Concept Study".FRONTIERS IN MEDICINE 9.(2022)
