机构:[1]Kunming Med Univ, Affiliated Hosp 6, Dept Dermatol & Venereol, Yuxi, Peoples R China[2]Kunming Med Univ, Affiliated Hosp 2, Dept Dermatol & Venereol, Kunming, Peoples R China[3]Ziyang Hosp Tradit Chinese Med, Dept Intense Care Unit, Ziyang, Peoples R China[4]Kunming Med Univ, Affiliated Hosp 6, Dept Gen Med, Yuxi, Peoples R China[5]Kunming Med Univ,Affiliated Hosp 1,Dept Dermatol & Venereol,Kunming,Peoples R China昆明医科大学附属第一医院内科科室皮肤科
Background: Eczema characterized by itch, sleeplessness, and adverse effects on quality of life is associated with a risk of hematological malignancies. However, there is a controversy pertaining to whether this association implies a greater or lesser risk of hematological cancers. We aimed to explore the link between eczema and hematological malignancies risk. Methods: We systematically searched PubMed and Embase databases from their inception to February 17, 2022. Two reviewers independently screened articles, extracted data and assessed study quality, respectively. The odds ratios and 95% confidence intervals (CIs) were pooled by using fixed or random-effects models. Results: 29 studies involving 2,521,574 participants examined the contribution of eczema to hematological malignancies. We found that eczema significantly increased the risk of Hodgkin's lymphoma (1.44; 95% CI, 1.07-1.95), myeloma (1.15; 95% CI, 1.04-1.28), and significantly decreased the risk of lymphocytic leukemia (0.91; 95% CI, 0.84-0.99); however, it is not significantly associated with Non-Hodgkin's lymphoma, and myelocytic leukemia. Conclusion: Eczema has been shown to be associated with the risk of hematological cancer, this association still needs to be verified in large randomized controlled trials.
基金:
National Natural Science Foundation of China [81760136, 31960136]; Special and Joint Program of Yunnan Provincial Science and Technology Department and Kunming Medical University [202001AY070001-097]; Yunnan health training project of high level talents; Scientific Research Fund project of Yunnan Education Department [2021J0304, 2019J1308]
第一作者机构:[1]Kunming Med Univ, Affiliated Hosp 6, Dept Dermatol & Venereol, Yuxi, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[1]Kunming Med Univ, Affiliated Hosp 6, Dept Dermatol & Venereol, Yuxi, Peoples R China[5]Kunming Med Univ,Affiliated Hosp 1,Dept Dermatol & Venereol,Kunming,Peoples R China
推荐引用方式(GB/T 7714):
Liang Zuohui,Liu Jie,Jin Hongxia,et al.Potential Correlation Between Eczema and Hematological Malignancies Risk: A Systematic Review and Meta-Analysis[J].FRONTIERS IN MEDICINE.2022,9:doi:10.3389/fmed.2022.912136.
APA:
Liang, Zuohui,Liu, Jie,Jin, Hongxia,Teng, Yirong,Xu, Shuangyan...&Zhu, Yun.(2022).Potential Correlation Between Eczema and Hematological Malignancies Risk: A Systematic Review and Meta-Analysis.FRONTIERS IN MEDICINE,9,
MLA:
Liang, Zuohui,et al."Potential Correlation Between Eczema and Hematological Malignancies Risk: A Systematic Review and Meta-Analysis".FRONTIERS IN MEDICINE 9.(2022)