机构：[1]Kunming Medical University, Kunming, China,[2]Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, China,内科科室消化内科昆明医科大学附属第一医院[3]Yunnan Province Clinical Research Center for Digestive Diseases, Kunming, China,[4]Department of Ultrasound, First Affiliated Hospital of Kunming Medical University, Kunming, China,医技科室超声科昆明医科大学附属第一医院[5]Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, Kunming, China外科科室器官移植中心昆明医科大学附属第一医院
The overactivation of NLRP3 inflammasome in intestinal epithelial cells (IECs) is among the important reasons for severe inflammation in ulcerative colitis (UC). We found that heat shock transcription factor 2 (HSF2), which is highly expressed in UC, could inhibit the activation of NLRP3 inflammasome and reduce IL-1 beta in IECs, but the mechanisms were still not clear. It has been reported that HSP72 regulated by HSF2 can enhance the mitophagy mediated by Parkin. The number of damaged mitochondria and the mitochondrial derived ROS (mtROS) can be reduced by mitophagy, which means the activity of NLRP3 inflammasome is inhibited. Therefore, we speculate that HSF2 might regulate the activation of NLRP3 inflammasome of IECs in UC through the mitophagy mediated by Parkin. This study proves that the number of damaged mitochondria in IECs, the level of mitophagy, and the level of ROS in intestinal mucosa are positively correlated with the severity of UC. In mice and cells, mitophagy was promoted by HSF2 through the PARL/PINK1/Parkin pathway. This study reveals the potential mechanisms of HSF2 decreasing mtROS of IECs in UC.
基金：
This work was supported by National Natural Science
Foundation of China (U1802282, 81960108, 82170550,
82160107); Applied Basic Research Projects of Yunnan
Province [2019FE001(036)]; Medicine Leading Talent of
Health and Family Planning Commission of Yunnan Province
(L-201607); Yunnan Health Training Project of High Level
Talents (H-2019050); Yunnan Ten Thousand Talents Plan
Young & Elite Talents Project.
第一作者机构：[1]Kunming Medical University, Kunming, China,[2]Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, China,[3]Yunnan Province Clinical Research Center for Digestive Diseases, Kunming, China,
共同第一作者：
通讯作者：
通讯机构：[2]Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, China,[3]Yunnan Province Clinical Research Center for Digestive Diseases, Kunming, China,
推荐引用方式(GB/T 7714)：
Liang Hao,Zhang Fengrui,Wang Wen,et al.Heat Shock Transcription Factor 2 Promotes Mitophagy of Intestinal Epithelial Cells Through PARL/PINK1/Parkin Pathway in Ulcerative Colitis[J].FRONTIERS IN PHARMACOLOGY.2022,13:doi:10.3389/fphar.2022.893426.
APA：
Liang, Hao,Zhang, Fengrui,Wang, Wen,Zhao, Wei,Zhou, Jiao...&Miao, Yinglei.(2022).Heat Shock Transcription Factor 2 Promotes Mitophagy of Intestinal Epithelial Cells Through PARL/PINK1/Parkin Pathway in Ulcerative Colitis.FRONTIERS IN PHARMACOLOGY,13,
MLA：
Liang, Hao,et al."Heat Shock Transcription Factor 2 Promotes Mitophagy of Intestinal Epithelial Cells Through PARL/PINK1/Parkin Pathway in Ulcerative Colitis".FRONTIERS IN PHARMACOLOGY 13.(2022)
