机构：[1]The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China昆明医科大学附属第一医院器官移植中心外科科室[2]Yunnan Province Clinical Research Center for Digestive Diseases, Kunming 650032, China.
Background Upregulation of Stathmin 1 (STMN1), a cytoplasmic phosphoprotein that controls the dynamics of cellular microtubules, is linked to malignant behavior and poor prognosis in a range of malignancies. However, little research has been done on STMN1's potential role in HCC as a single factor in DNA methylation, m(6)A, or immunological modulation. Results STMN1 is overexpressed in hepatocellular carcinoma, where it is related to clinicopathological parameters and affects the prognosis of HCC patients. STMN1 overexpression plays an important role in the diagnosis and prognosis of hepatocellular carcinoma. Meanwhile, methylation of 7 CpG sites of STMN1 in HCC was correlated with prognosis, and STMN1 expression was closely related to m(6)A modification. In addition, STMN1 expression is associated with immune cell infiltration, immune molecules, and immune checkpoints in HCC. Conclusion STMN1 has a significant role in hepatocellular carcinoma diagnosis and prediction. STMN1 is implicated not just in the onset and course but also in the immunological modulation of the disease. DNA methylation and m(6)A are both linked to STMN1. Therefore, STMN1 could be used as a diagnostic and prognostic biomarker for HCC, as well as a target for immunotherapy.
基金：
National Natural Science Foundation of China [81960123]; Yunnan Provincial Science and Technology Department; Kunming Medical University [2019FE001-037]
第一作者机构：[1]The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
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推荐引用方式(GB/T 7714)：
Zhang En-di,Li Chenxuan,Fang Yuan,et al.STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation[J].WORLD JOURNAL OF SURGICAL ONCOLOGY.2022,20(1):doi:10.1186/s12957-022-02768-y.
APA：
Zhang, En-di,Li, Chenxuan,Fang, Yuan,Li, Na,Xiao, Zhongyun...&Huang, Hanfei.(2022).STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation.WORLD JOURNAL OF SURGICAL ONCOLOGY,20,(1)
MLA：
Zhang, En-di,et al."STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation".WORLD JOURNAL OF SURGICAL ONCOLOGY 20..1(2022)
