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A promising research direction for colorectal cancer immunotherapy: The regulatory mechanism of CCL5 in colorectal cancer

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收录情况： ◇ SCIE

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机构： [1]Kunming Med Univ, Affiliated Hosp 1, Dept Gastrointestinal & Hernia Surg, Kunming, Peoples R China [2]Kunming Med Univ, Natl Hlth Commiss NHC Key Lab Drug Addict Med, Kunming, Peoples R China [3]Yunnan Univ, Affiliated Hosp, Kunming, Yunnan, Peoples R China [4]Yanan Hosp Kunming City, Kunming, Yunnan, Peoples R China [5]Kunming Med Univ, Affiliated Hosp 1, Yunnan Inst Digest Dis, Kunming, Yunnan, Peoples R China

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关键词： colorectal cancer immunotherapy chemokines CCL5 the tumor microenvironment

摘要：

Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide, with high morbidity and mortality rates worldwide. Therefore, there is an urgent need to develop more effective treatments for CRC patients. In recent years, there has been some success in the immunotherapy of tumors, and immunotherapy has been used in many solid tumors including CRC. To date, the clinical efficacy of immunotherapy for CRC is limited, so more effective immunotherapy methods need to be explored. In patients with CRC, the CC chemokine CCL5 plays a role in the development of CRC and the recruitment and activation of immune cells, suggesting that it has potential for immunotherapy. This review mainly introduces the latest advances in the study of CCL5 acting as a marker of CRC and related mechanisms of immunotherapy, as well as the latest understanding of how CCL5 is involved in the invasion and development of CRC.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

JCR分区：

出版当年[2022]版：

Q2 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 3.5 最新[2023版] 4 最新五年平均 4.7 出版当年[2022版] 5.2 出版当年五年平均 5.738 出版前一年[2021版] 3.5 出版后一年[2023版]

第一作者：

第一作者机构： [1]Kunming Med Univ, Affiliated Hosp 1, Dept Gastrointestinal & Hernia Surg, Kunming, Peoples R China [2]Kunming Med Univ, Natl Hlth Commiss NHC Key Lab Drug Addict Med, Kunming, Peoples R China

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通讯作者：

通讯机构： [1]Kunming Med Univ, Affiliated Hosp 1, Dept Gastrointestinal & Hernia Surg, Kunming, Peoples R China [2]Kunming Med Univ, Natl Hlth Commiss NHC Key Lab Drug Addict Med, Kunming, Peoples R China [5]Kunming Med Univ, Affiliated Hosp 1, Yunnan Inst Digest Dis, Kunming, Yunnan, Peoples R China

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