机构：[1]Cent South Univ, Xiangya Hosp, Dept Nutr, Changsha, Peoples R China[2]Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Peoples R China[3]Kunming Med Univ,Affiliated Hosp 1,Dept Reprod & Genet,Kunming,Peoples R China昆明医科大学附属第一医院外科科室生殖遗传科[4]Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
Diabetic nephropathy (DN) involves serious lipid metabolism disorder, and renal ectopic lipid deposition aggravates DN progression. However, the molecular mechanism of renal lipid deposition in DN remains unclear. Lipid droplets (LDs) are lipid pools in cells that change dynamically in response to the cellular energy needs. The LDs and mitochondria are connected through a part of the mitochondria known as the peridroplet mitochondria (PDM). In this review, we summarize the definition, detection methods, and function of the PDM. Finally, we discuss the research status of PDM in DN and the possibility of its use as a therapeutic target.
基金：
National Natural Science Foundation of China; [81900069]; [82000697]
第一作者机构：[1]Cent South Univ, Xiangya Hosp, Dept Nutr, Changsha, Peoples R China[2]Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Peoples R China
通讯作者：
通讯机构：[1]Cent South Univ, Xiangya Hosp, Dept Nutr, Changsha, Peoples R China[4]Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Ming,Luo Shilu,Yang Jinfei,et al.Lipid droplet-mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy[J].FRONTIERS IN ENDOCRINOLOGY.2022,13:doi:10.3389/fendo.2022.1017387.
APA：
Yang, Ming,Luo, Shilu,Yang, Jinfei,Chen, Wei,He, Liyu...&Wang, Xi.(2022).Lipid droplet-mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy.FRONTIERS IN ENDOCRINOLOGY,13,
MLA：
Yang, Ming,et al."Lipid droplet-mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy".FRONTIERS IN ENDOCRINOLOGY 13.(2022)
