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Functions and clinical significance of circular RNAs in acute myeloid leukemia

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机构： [1]School of Life Sciences, Chongqing University, Chongqing, China. [2]Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, Chongqing, China. [3]Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, China. [4]Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China. [5]Department of Anesthesiology, The First People's Hospital of Yunnan Province, Kunming, China. [6]Department of Anesthesiology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

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关键词： circular RNAs acute myeloid leukemia molecular functions clinical significance role

摘要：

Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNA molecules. Four types of circRNAs have been reported in animal cells, and they have typical characteristics in their biogenesis, nuclear export and degradation. Advances in our understanding of the molecular functions of circRNAs in sponging microRNAs, modulating transcription, regulating RNA-binding proteins, as well as encoding proteins have been made very recently. Dysregulated circRNAs are associated with human diseases such as acute myeloid leukemia (AML). In this review, we focus on the recently described mechanisms, role and clinical significance of circRNAs in AML. Although great progress of circRNAs in AML has been achieved, substantial efforts are still required to explore whether circRNAs exert their biological function by other mechanisms such as regulation of gene transcription or serving as translation template in AML. It is also urgent that researchers study the machineries regulating circRNAs fate, the downstream effectors of circRNAs modulatory networks, and the clinical application of circRNAs in AML.Copyright © 2022 Zhou, Gao, Zheng and Luo.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区药学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区药学

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出版当年[2022]版：

Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.4 最新[2023版] 5 最新五年平均 5.6 出版当年[2022版] 6.1 出版当年五年平均 5.988 出版前一年[2021版] 4.4 出版后一年[2023版]

第一作者：

第一作者机构： [1]School of Life Sciences, Chongqing University, Chongqing, China. [2]Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, Chongqing, China.

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通讯机构： [1]School of Life Sciences, Chongqing University, Chongqing, China. [2]Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, Chongqing, China. [5]Department of Anesthesiology, The First People's Hospital of Yunnan Province, Kunming, China. [6]Department of Anesthesiology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

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