机构：[1]Department of Clinical Laboratory,the First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,P.R. China,昆明医科大学附属第一医院医技科室医学检验科[2]Yunnan Key Laboratory of Laboratory Medicine, Kunming, Yunnan, P.R. China,[3]Yunnan Innovation Team of Clinical Laboratory and Diagnosis,the First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,P.R. China,昆明医科大学附属第一医院[4]Yunnan Province Clinical Research Center for Laboratory Medicine, Kunming, Yunnan, P.R. China[5]Department of Clinical Laboratory, the Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, P.R. China.
Acute myeloid leukemia (AML), an uncommonly low 5-year survival and high mortality rate, is a potentially catastrophic diagnosed subtype of leukemia. The development of new prognostic markers is urgently needed to guide its treatment. Necroptosis is a newly defined biological process for regulating cell death, and previous studies have confirmed that the abnormality of the physical function can lead to multiple malignancies. Here, we performed necroptosis-related genes (NRGs) to build a predictive model in the Cancer Genome Atlas (TCGA)-AML patients, thus exploring the correlation between the NRG prognosis signature (NRG score) of this model and immune infiltration, pathway activity, clinical features, and immunotherapy. Besides, we computed the statistical measure Spearman rank correlation between the NRG score and the Log IC50 values of therapeutic agents. Subsequently, we divided the TCGA-AML cohort into 2 groups, one with high scores and the other with low scores depending on the model score. AML patients with high NRG scores exhibited a lower estimated overall survival (OS) rate than those with low NRG scores, which was confirmed in the validation set. The prognostic value of the constructed NRG signature to the AML, independent of other variables, was demonstrated by uni- and multivariate stepwise regression analysis. When comparing the infiltrating states of specialized cells associated with immune system from the 2 groups, B cells naive, Plasma cells, and monocytes represented significant differences among various subgroups of samples. Moreover, the 30 hallmark-related pathways related to necroptosis characteristics were remarkably different between the high/low NRG score groups. And patients showed remarkable NRG score distribution in clinical features of bone marrow lymphocyte, category, and FAB classifications. Besides, we found that the BIRB0796, VX680, Vorinostat, and Axitinib positively related with NRG score, whereas CI. 1040, PD. 0325901, Z.L LNle. CHO, and AZD6244 negatively correlated with the NRG score. These drugs may provide a reference for subsequent treatment.
基金：
Joint Project of Yunnan Provincial Department of Science and Technology and Kunming Medical University [202001AY070001-239]; Yunnan Medical Laboratory Clinical Medical Research Center special fund subproject [202102AA100063-06]
第一作者机构：[1]Department of Clinical Laboratory,the First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,P.R. China,[2]Yunnan Key Laboratory of Laboratory Medicine, Kunming, Yunnan, P.R. China,[3]Yunnan Innovation Team of Clinical Laboratory and Diagnosis,the First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,P.R. China,[4]Yunnan Province Clinical Research Center for Laboratory Medicine, Kunming, Yunnan, P.R. China
通讯作者：
通讯机构：[1]Department of Clinical Laboratory,the First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,P.R. China,[2]Yunnan Key Laboratory of Laboratory Medicine, Kunming, Yunnan, P.R. China,[3]Yunnan Innovation Team of Clinical Laboratory and Diagnosis,the First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,P.R. China,[4]Yunnan Province Clinical Research Center for Laboratory Medicine, Kunming, Yunnan, P.R. China
推荐引用方式(GB/T 7714)：
Pan Yu-Qing,Yang Kai,Zhang Xi,et al.Construction and validation of a necroptosis-related prognostic signature in acute myeloid leukemia[J].MEDICINE.2024,103(22):doi:10.1097/MD.0000000000038432.
APA：
Pan, Yu-Qing,Yang, Kai,Zhang, Xi,Li, Yi-Xun,Guo, Chong...&Du, Yan.(2024).Construction and validation of a necroptosis-related prognostic signature in acute myeloid leukemia.MEDICINE,103,(22)
MLA：
Pan, Yu-Qing,et al."Construction and validation of a necroptosis-related prognostic signature in acute myeloid leukemia".MEDICINE 103..22(2024)
